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Self-Assembly of Peptide−Amphiphile Nanofibers: The Roles of Hydrogen Bonding and Amphiphilic Packing
Abstract
The role of hydrogen bonding and amphiphilic packing in the self-assembly of peptide-amphiphiles (PAs) was investigated using a series of 26 PA derivatives, including 19 N-methylated variants and 7 alanine mutants. These were studied by circular dichroism spectroscopy, a variety of Fourier transform infrared spectroscopies, rheology, and vitreous ice cryo-transmission electron microscopy. From these studies, we have been able to determine which amino acids are critical for the self-assembly of PAs into nanofibers, why the nanofiber is favored over other possible nanostructures, the orientation of hydrogen bonding with respect to the nanofiber axis, and the constraints placed upon the portion of the peptide most intimately associated with the biological environment. Furthermore, by selectively eliminating key hydrogen bonds, we are able to completely change the nanostructure resulting from self-assembly in addition to modifying the macroscopic mechanical properties associated with the assembled gel. This study helps to clarify the mechanism of self-assembly for peptide amphiphiles and will thereby help in the design of future generations of PAs.
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Cited by
Molecular self-assembly and applications of designer peptide amphiphiles
Zhao, X., Pan, F., Xu, H., Yaseen, M., Shan, H., Hauser, C. A. E., Zhang, S., & Lu, J. R. (2010) · Chemical Society Reviews · doi:10.1039/b915923c · Cited by 668
Supramolecular Chemistry and Self-Assembly in Organic Materials Design
Stupp, S. I., & Palmer, L. C. (2014) · Chemistry of Materials · doi:10.1021/cm403028b · Cited by 513
Design and applications of man-made biomimetic fibrillar hydrogels
Prince, E., & Kumacheva, E. (2019) · Nature Reviews Materials · doi:10.1038/s41578-018-0077-9 · Cited by 379
Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354
Dong, H., Paramonov, S. E., Aulisa, L., Bakota, E. L., & Hartgerink, J. D. (2007) · Journal of the American Chemical Society · doi:10.1021/ja072536r · Cited by 344
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Metadata
- Authors
- Paramonov, S. E., Jun, H.-W., & Hartgerink, J. D.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-05-16
- Volume
- 128
- Issue
- 22
- Pages
- 7291-7298
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1980699575
- Cited by
- 675
- References
- 0
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Paramonov, S. E., Jun, H.-W., & Hartgerink, J. D. (2006). Self-Assembly of Peptide−Amphiphile Nanofibers: The Roles of Hydrogen Bonding and Amphiphilic Packing. Journal of the American Chemical Society. https://doi.org/10.1021/ja060573x
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