The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
FePt@CoS2 Yolk−Shell Nanocrystals as a Potent Agent to Kill HeLa Cells
Abstract
We report the evaluation of cytotoxicity of a new type of engineered nanomaterials, FePt@CoS(2) yolk-shell nanocrystals, synthesized by the mechanism of the Kirkendall effect when FePt nanoparticles serve as the seeds. The cytotoxicity of FePt@CoS(2) yolk-shell nanocrystals, evaluated by MTT assay, shows a much lower IC(50) (35.5 +/- 4.7 ng of Pt/mL for HeLa cell) than that of cisplatin (230 ng of Pt/mL). In the control experiment, cysteine-modified FePt nanoparticles exhibit IC50 at 12.0 +/- 0.9 microg of Pt/mL. Transmission electron microscopy confirms the cellular uptake of FePt@CoS(2) nanocrystals, and the magnetic properties analysis (SQUID) proves the release of FePt nanoparticles from the yolk-shell nanostructures after cellular uptake. These results are significant because almost none of the platinum-based complexes produced for clinical trials in the past 3 decades have shown higher activity than that of the parent drug, cisplatin. The exceptionally high toxicity of FePt@CoS(2) yolk-shell nanocrystals (about 7 times higher than that of cisplatin in terms of Pt) may lead to a new design of an anticancer nanomedicine.
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Citations
Cites
Monodisperse FePt Nanoparticles and Ferromagnetic FePt Nanocrystal Superlattices
Sun, S., Murray, C. B., Weller, D., Folks, L., & Moser, A. (2000) · Science · doi:10.1126/science.287.5460.1989 · Cited by 6,137
One-Step Synthesis of FePt Nanoparticles with Tunable Size
Chen, M., Liu, J. P., & Sun, S. (2004) · Journal of the American Chemical Society · doi:10.1021/ja047648m · Cited by 368
Cited by
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications
Gao, J., Gu, H., & Xu, B. (2009) · Accounts of Chemical Research · doi:10.1021/ar9000026 · Cited by 1,907
Self-citationSynthesis, Properties, and Applications of Hollow Micro-/Nanostructures
Wang, X., Feng, J., Bai, Y., Zhang, Q., & Yin, Y. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00731 · Cited by 1,456
Platinum-Based Nanostructured Materials: Synthesis, Properties, and Applications
Chen, A., & Holt-Hindle, P. (2010) · Chemical Reviews · doi:10.1021/cr9003902 · Cited by 1,390
Colloidal heterostructured nanocrystals: Synthesis and growth mechanisms
Carbone, L., & Cozzoli, P. D. (2010) · Nano Today · doi:10.1016/j.nantod.2010.08.006 · Cited by 691
Metadata
- Authors
- Gao, J., Liang, G., Zhang, B., Kuang, Y., Zhang, X., & Xu, B.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-01-11
- Volume
- 129
- Issue
- 5
- Pages
- 1428-1433
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2117986744
- Cited by
- 403
- References
- 2
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- closed
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