The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Helix Bundle Quaternary Structure from α/β-Peptide Foldamers
Abstract
The function of a protein generally depends on adoption of a specific folding pattern, which in turn is determined by the side chain sequence along the polypeptide backbone. Here we show that the sequence-encoded structural information in peptides derived from yeast transcriptional activator GCN4 can be used to prepare hybrid α/β-peptide foldamers that adopt helix bundle quaternary structures. Crystal structures of two hybrid α/β-peptides are reported along with detailed structural comparison to α-peptides of analogous side chain sequence. There is considerable homology between α- and α/β-peptides at the level of helical secondary structure, with modest but significant differences in the association geometry of helices in the quaternary structure.
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Citations
Cites
The packing of α-helices: simple coiled-coils
Crick, F. H. C. (1953) · Acta Crystallographica · doi:10.1107/s0365110x53001964 · Cited by 1,578
A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants
Harbury, P. B., Zhang, T., Kim, P. S., & Alber, T. (1993) · Science · doi:10.1126/science.8248779 · Cited by 1,490
Cited by
Peptidic foldamers: ramping up diversity
Martinek, T. A., & Fülöp, F. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15097a · Cited by 485
Vasudev, P. G., Chatterjee, S., Shamala, N., & Balaram, P. (2011) · Chemical Reviews · doi:10.1021/cr100100x · Cited by 329
CC + : A searchable database of validated coiled coils in PDB structures and AlphaFold2 models
Kumar, P., Petrenas, R., Dawson, W. M., Schweke, H., Levy, E. D., & Woolfson, D. N. (2023) · Protein Science · doi:10.1002/pro.4789 · Cited by 11
“Interestingly, helical α/β-peptide foldamers (PDB IDs: 2oxj, 2oxk, and 3c3g) from the Gellman lab were identified as CCs by Socket2 and found to have a total of 7 nonproteogenic residues in CC helices, the highest number found to date.(34,35)”
BackgroundMethod
Metadata
- Authors
- Horne, W. S., Price, J. L., Keck, J. L., & Gellman, S. H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-03-16
- Volume
- 129
- Issue
- 14
- Pages
- 4178-4180
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2158161135
- Cited by
- 200
- References
- 2
- FWCI
- 8.26
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
