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Label-Free Detection of DNA Hybridization Using Surface Enhanced Raman Spectroscopy
Abstract
The SERS spectrum of DNA is strongly dominated by the strong spectral feature of adenine at 736 cm(-1); the presence of adenine can serve as an endogenous marker for the label-free SERS-based detection of DNA hybridization when the probe DNA sequence is adenine-free. The substitution of 2-aminopurine for adenine on the probe DNA sequence enables the detection of a target sequence using SERS, upon hybridization of the target with the 2-AP-substituted probe DNA sequence.
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Cited by
Plasmonic Nanoclusters: Near Field Properties of the Fano Resonance Interrogated with SERS
Ye, J., Wen, F., Sobhani, H., Lassiter, J. B., Van Dorpe, P., Nordlander, P., & Halas, N. J. (2012) · Nano Letters · doi:10.1021/nl3000453 · Cited by 478
Self-citationMultiplex in vitro detection using SERS
Laing, S., Gracie, K., & Faulds, K. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00644a · Cited by 361
A review of aptamer-based SERS biosensors: Design strategies and applications
Muhammad, M., & Huang, Q. (2021) · Talanta · doi:10.1016/j.talanta.2021.122188 · Cited by 179
Kong, K. V., Lam, Z., Lau, W. K. O., Leong, W. K., & Olivo, M. (2013) · Journal of the American Chemical Society · doi:10.1021/ja409230g · Cited by 173
Simultaneous detection and quantification of three bacterial meningitis pathogens by SERS
Gracie, K., Correa, E., Mabbott, S., Dougan, J. A., Graham, D., Goodacre, R., & Faulds, K. (2014) · Chem. Sci. · doi:10.1039/c3sc52875h · Cited by 161
Metadata
- Authors
- Barhoumi, A., & Halas, N. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-08-25
- Volume
- 132
- Issue
- 37
- Pages
- 12792-12793
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2045083682
- Cited by
- 261
- References
- 0
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- closed
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