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Label-Free Biosensors Based on Aptamer-Modified Graphene Field-Effect Transistors
Abstract
A label-free immunosensor based on an aptamer-modified graphene field-effect transistor (G-FET) is demonstrated. Immunoglobulin E (IgE) aptamers with an approximate height of 3 nm were successfully immobilized on a graphene surface, as confirmed by atomic force microscopy. The aptamer-modified G-FET showed selective electrical detection of IgE protein. From the dependence of the drain current variation on the IgE concentration, the dissociation constant was estimated to be 47 nM, indicating good affinity and the potential for G-FETs to be used in biological sensors.
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Cites
Geim, A. K., & Novoselov, K. S. (2007) · Nature Materials · doi:10.1038/nmat1849 · Cited by 39,979
Cited by
Hammock, M. L., Chortos, A., Tee, B. C. ‐., Tok, J. B. ‐., & Bao, Z. (2013) · Advanced Materials · doi:10.1002/adma.201302240 · Cited by 2,396
MoS2 Field-Effect Transistor for Next-Generation Label-Free Biosensors
Sarkar, D., Liu, W., Xie, X., Anselmo, A. C., Mitragotri, S., & Banerjee, K. (2014) · ACS Nano · doi:10.1021/nn5009148 · Cited by 1,047
Pumera, M. (2011) · Materials Today · doi:10.1016/s1369-7021(11)70160-2 · Cited by 851
Graphene-based electronic sensors
He, Q., Wu, S., Yin, Z., & Zhang, H. (2012) · Chemical Science · doi:10.1039/c2sc20205k · Cited by 745
New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide
Feng, L., Wu, L., & Qu, X. (2013) · Advanced Materials · doi:10.1002/adma.201203229 · Cited by 632
Metadata
- Authors
- Ohno, Y., Maehashi, K., & Matsumoto, K.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-12-03
- Volume
- 132
- Issue
- 51
- Pages
- 18012-18013
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2065599687
- Cited by
- 554
- References
- 1
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ohno, Y., Maehashi, K., & Matsumoto, K. (2010). Label-Free Biosensors Based on Aptamer-Modified Graphene Field-Effect Transistors. Journal of the American Chemical Society. https://doi.org/10.1021/ja108127r
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
