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A Biocompatible Oxidation-Triggered Carrier Polymer with Potential in Therapeutics
Abstract
Dextran, a water-soluble, biocompatible polymer of glucose, was modified at its hydroxyls with arylboronic esters to make it soluble in common organic solvents, allowing for the facile preparation of oxidation-sensitive dextran (Oxi-DEX) carrier microparticles. These particles were found to release their payload with a half-life of 36 min at 1 mM H2O2, which can be compared with a half-life of greater than 1 week in the absence of H2O2. When used in a model vaccine application, Oxi-DEX particles loaded with ovalbumin (OVA) increased the presentation to CD8+ T-cells 27-fold relative to OVA encapsulated in a classical vehicle not sensitive to oxidation. No presentation was observed from cells incubated with unencapsulated OVA. Additionally, Oxi-DEX was found to be nontoxic in preliminary in vitro cytotoxicity assays. Because it is easy to prepare, sensitive to biological oxidation, and biocompatible, this material may represent an attractive new platform for selective delivery applications.
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Cited by
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
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Chan, J., Dodani, S. C., & Chang, C. J. (2012) · Nature Chemistry · doi:10.1038/nchem.1500 · Cited by 1,883
Fleige, E., Quadir, M. A., & Haag, R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.020 · Cited by 1,111
Yusuf, A., Almotairy, A. R. Z., Henidi, H., Alshehri, O. Y., & Aldughaim, M. S. (2023) · Polymers · doi:10.3390/polym15071596 · Cited by 914
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 855
Metadata
- Authors
- Broaders, K. E., Grandhe, S., & Fréchet, J. M. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-12-20
- Volume
- 133
- Issue
- 4
- Pages
- 756-758
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2069119383
- Cited by
- 392
- References
- 0
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Broaders, K. E., Grandhe, S., & Fréchet, J. M. J. (2011). A Biocompatible Oxidation-Triggered Carrier Polymer with Potential in Therapeutics. Journal of the American Chemical Society. https://doi.org/10.1021/ja110468v
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
