The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents
Abstract
Strained ruthenium (Ru) complexes have been synthesized and characterized as novel agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible light, which induces ligand loss and covalent modification of DNA. An increase in cytotoxicity of 2 orders of magnitude is observed with light activation in cancer cells, and the compounds display potencies superior to cisplatin against 3D tumor spheroids. The use of intramolecular strain may be applied as a general paradigm to develop light-activated ruthenium complexes for PDT applications.
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Cites
Spheroid-based drug screen: Considerations and practical approach
Friedrich, J., Seidel, C., Ebner, R., & Kunz-Schughart, L. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.226 · Cited by 1,742
The use of 3-d cultures for high-throughput screening: the multicellular spheroid model.
Kunz-Schughart, L. A., Freyer, J. P., Hofstaedter, F., & Ebner, R. (2004) · SLAS DISCOVERY · doi:10.1177/1087057104265040 · Cited by 797
Cited by
Prier, C. K., Rankic, D. A., & MacMillan, D. W. C. (2013) · Chemical Reviews · doi:10.1021/cr300503r · Cited by 9,590
Lee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
Metadata
- Authors
- Howerton, B. S., Heidary, D. K., & Glazer, E. C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-11
- Volume
- 134
- Issue
- 20
- Pages
- 8324-8327
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2058030197
- Cited by
- 498
- References
- 2
- FWCI
- 16.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Howerton, B. S., Heidary, D. K., & Glazer, E. C. (2012). Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents. Journal of the American Chemical Society. https://doi.org/10.1021/ja3009677
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
