The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Reaction-Based Genetically Encoded Fluorescent Hydrogen Sulfide Sensors
Abstract
The detection of hydrogen sulfide (H(2)S), a toxic gas and an important biological signaling molecule, has been a long-time challenge. Here we report genetically encoded fluorescent protein (FP)-based probes that can selectively detect H(2)S. By expanding the genetic codes of E. coli and mammalian cells, FP chromophores were modified with the sulfide-reactive azide functional group. These structurally modified chromophores were selectively reduced by H(2)S, resulting in sensitive fluorescence enhancement detectable by spectroscopic and microscopic techniques. Exploration of a circularly permuted FP led to an improved sensor with faster responses, and the feasibility of using such a genetically encoded probe to monitor H(2)S in living mammalian cells has also been demonstrated.
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Cites
Adding New Chemistries to the Genetic Code
Liu, C. C., & Schultz, P. G. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.105824 · Cited by 1,725
Hydrogen sulfide-releasing anti-inflammatory drugs
Wallace, J. L. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.09.003 · Cited by 328
Cited by
Carbon quantum dots and their applications
Lim, S. Y., Shen, W., & Gao, Z. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00269e · Cited by 4,976
Reaction-based small-molecule fluorescent probes for chemoselective bioimaging
Chan, J., Dodani, S. C., & Chang, C. J. (2012) · Nature Chemistry · doi:10.1038/nchem.1500 · Cited by 1,883
Yu, C., Li, X., Zeng, F., Zheng, F., & Wu, S. (2013) · Chem. Commun. · doi:10.1039/c2cc37329g · Cited by 455
Bae, S. K., Heo, C. H., Choi, D. J., Sen, D., Joe, E.-H., Cho, B. R., & Kim, H. M. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404004v · Cited by 411
Chemical foundations of hydrogen sulfide biology
Li, Q., & Lancaster, J. R. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.001 · Cited by 334
Metadata
- Authors
- Chen, S., Chen, Z.-J., Ren, W., & Ai, H.-W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-05-31
- Volume
- 134
- Issue
- 23
- Pages
- 9589-9592
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2333590887
- Cited by
- 318
- References
- 2
- FWCI
- 17.37
- Type
- journal article
- Language
- en
- Open access
- closed
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