The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry
Open accessAbstract
Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other. Dynamic combinatorial libraries (DCLs) are powerful tools for discovering the unexpected and have given rise to many fascinating molecules, ranging from interlocked structures to self-replicators. Furthermore, dynamic combinatorial molecular networks can produce emergent properties at systems level, which provide exciting new opportunities in systems chemistry. In this perspective we will highlight some new methodologies in this field and analyze selected examples of DCLs that are under thermodynamic control, leading to synthetic receptors, catalytic systems, and complex self-assembled supramolecular architectures. Also reviewed are extensions of the principles of DCC to systems that are not at equilibrium and may therefore harbor richer functional behavior. Examples include self-replication and molecular machines.
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Cites
Fragment-Based Approaches in Drug Discovery and Chemical Biology
Scott, D. E., Coyne, A. G., Hudson, S. A., & Abell, C. (2012) · Biochemistry · doi:10.1021/bi3005126 · Cited by 460
Whitesides, G. M., & Ismagilov, R. F. (1999) · Science · doi:10.1126/science.284.5411.89 · Cited by 423
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Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354
Diversification of self-replicating molecules
Sadownik, J. W., Mattia, E., Nowak, P., & Otto, S. (2016) · Nature Chemistry · doi:10.1038/nchem.2419 · Cited by 214
Self-citationPrimitive selection of the fittest emerging through functional synergy in nucleopeptide networks
Bandela, A. K., Wagner, N., Sadihov, H., Morales-Reina, S., Chotera-Ouda, A., Basu, K., Cohen-Luria, R., de la Escosura, A., & Ashkenasy, G. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015285118 · Cited by 49
A Bistable Switch in Dynamic Thiodepsipeptide Folding and Template‐Directed Ligation
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Metadata
- Authors
- Li, J., Nowak, P., & Otto, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-06-11
- Volume
- 135
- Issue
- 25
- Pages
- 9222-9239
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2120520995
- Cited by
- 493
- References
- 2
- FWCI
- 25.00
- Type
- journal article
- Language
- en
- Open access
- green
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