The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Using Hollow Carbon Nanospheres as a Light-Induced Free Radical Generator To Overcome Chemotherapy Resistance
Abstract
Under evolutionary pressure from chemotherapy, cancer cells develop resistance characteristics such as a low redox state, which eventually leads to treatment failures. An attractive option for combatting resistance is producing a high concentration of produced free radicals in situ. Here, we report the production and use of dispersible hollow carbon nanospheres (HCSs) as a novel platform for delivering the drug doxorubicine (DOX) and generating additional cellular reactive oxygen species using near-infrared laser irradiation. These irradiated HCSs catalyzed sufficiently persistent free radicals to produce a large number of heat shock factor-1 protein homotrimers, thereby suppressing the activation and function of resistance-related genes. Laser irradiation also promoted the release of DOX from lysosomal DOX@HCSs into the cytoplasm so that it could enter cell nuclei. As a result, DOX@HCSs reduced the resistance of human breast cancer cells (MCF-7/ADR) to DOX through the synergy among photothermal effects, increased generation of free radicals, and chemotherapy with the aid of laser irradiation. HCSs can provide a unique and versatile platform for combatting chemotherapy-resistant cancer cells. These findings provide new clinical strategies and insights for the treatment of resistant cancers.
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Cites
Multidrug resistance in cancer: role of ATP–dependent transporters
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Targeting multidrug resistance in cancer
Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1984 · Cited by 3,609
Dual-pore mesoporous carbon@silica composite core-shell nanospheres for multidrug delivery
Fang, Y., Zheng, G., Yang, J., Tang, H., Zhang, Y., Kong, B., Lv, Y., Xu, C., Asiri, A. M., Zi, J., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201402002 · Cited by 198
Cited by
Peng, L., Hung, C.-T., Wang, S., Zhang, X., Zhu, X., Zhao, Z., Wang, C., Tang, Y., Li, W., & Zhao, D. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b02091 · Cited by 607
Self-citationPei, F., An, T., Zang, J., Zhao, X., Fang, X., Zheng, M., Dong, Q., & Zheng, N. (2016) · Advanced Energy Materials · doi:10.1002/aenm.201502539 · Cited by 555
Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance
Wang, H., Gao, Z., Liu, X., Agarwal, P., Zhao, S., Conroy, D. W., Ji, G., Yu, J., Jaroniec, C. P., Liu, Z., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02915-8 · Cited by 331
RetractedWang, S., Shang, L., Li, L., Yu, Y., Chi, C., Wang, K., Zhang, J., Shi, R., Shen, H., Waterhouse, G. I. N., et al. (2016) · Advanced Materials · doi:10.1002/adma.201602197 · Cited by 323
Metadata
- Authors
- Wang, L., Sun, Q., Wang, X., Wen, T., Yin, J.-J., Wang, P., Bai, R., Zhang, X.-Q., Zhang, L.-H., Lu, A.-H., & Chen, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-01-29
- Volume
- 137
- Issue
- 5
- Pages
- 1947-1955
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2060611150
- Cited by
- 204
- References
- 4
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- closed
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