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Antimicrobial Polymers Prepared by ROMP with Unprecedented Selectivity: A Molecular Construction Kit Approach
Open accessAbstract
Synthetic Mimics of Antimicrobial Peptides (SMAMPs) imitate natural host-defense peptides, a vital component of the body's immune system. This work presents a molecular construction kit that allows the easy and versatile synthesis of a broad variety of facially amphiphilic oxanorbornene-derived monomers. Their ring-opening metathesis polymerization (ROMP) and deprotection provide several series of SMAMPs. Using amphiphilicity, monomer feed ratio, and molecular weight as parameters, polymers with 533 times higher selectivitiy (selecitviy = hemolytic concentration/minimum inhibitory concentration) for bacteria over mammalian cells were discovered. Some of these polymers were 50 times more selective for Gram-positive over Gram-negative bacteria while other polymers surprisingly showed the opposite preference. This kind of "double selectivity" (bacteria over mammalian and one bacterial type over another) is unprecedented in other polymer systems and is attributed to the monomer's facial amphiphilicity.
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Citations
Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Cited by
Polymeric materials with antimicrobial activity
Muñoz-Bonilla, A., & Fernández-García, M. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.08.005 · Cited by 1,221
Cationic Antimicrobial Polymers and Their Assemblies
Carmona-Ribeiro, A., & De Melo Carrasco, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059906 · Cited by 532
Biomimetic antimicrobial polymers: recent advances in molecular design
Ergene, C., Yasuhara, K., & Palermo, E. F. (2018) · Polymer Chemistry · doi:10.1039/c8py00012c · Cited by 312
Cationic polymers and their self-assembly for antibacterial applications
Deka, S., Sharma, A., & Kumar, P. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150330110602 · Cited by 82
Metadata
- Authors
- Lienkamp, K., Madkour, A. E., Musante, A., Nelson, C. F., Nüsslein, K., & Tew, G. N.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-01
- Volume
- 130
- Issue
- 30
- Pages
- 9836-9843
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1971374993
- Cited by
- 418
- References
- 2
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Lienkamp, K., Madkour, A. E., Musante, A., Nelson, C. F., Nüsslein, K., & Tew, G. N. (2008). Antimicrobial Polymers Prepared by ROMP with Unprecedented Selectivity: A Molecular Construction Kit Approach. Journal of the American Chemical Society. https://doi.org/10.1021/ja801662y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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