The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Microfluidic Fabrication of Monodisperse Biocompatible and Biodegradable Polymersomes with Controlled Permeability
Abstract
We describe a versatile technique for fabricating monodisperse polymersomes with biocompatible and biodegradable diblock copolymers for efficient encapsulation of actives. We use double emulsion as a template for the assembly of amphiphilic diblock copolymers into vesicle structures. These polymersomes can be used to encapsulate small hydrophilic solutes. When triggered by an osmotic shock, the polymersomes break and release the solutes, providing a simple and effective release mechanism. The technique can also be applied to diblock copolymers with different hydrophilic-to-hydrophobic block ratios, or mixtures of diblock copolymers and hydrophobic homopolymers. The ability to make polymer vesicles with copolymers of different block ratios and to incorporate different homopolymers into the polymersomes will allow the tuning of polymersome properties for specific technological applications.
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Cites
Discher, D. E., & Ahmed, F. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095838 · Cited by 844
Stealth PLA-PEG nanoparticles as protein carriers for nasal administration
Tobío, M., Gref, R., Sánchez, A., Langer, R., & Alonso, M. J. (1998) · Pharmaceutical Research · doi:10.1023/a:1011922819926 · Cited by 402
Cited by
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500
Seemann, R., Brinkmann, M., Pfohl, T., & Herminghaus, S. (2012) · Reports on Progress in Physics · doi:10.1088/0034-4885/75/1/016601 · Cited by 1,049
Motornov, M., Roiter, Y., Tokarev, I., & Minko, S. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.10.004 · Cited by 773
Synthesis of micro and nanostructures in microfluidic systems
Marre, S., & Jensen, K. F. (2010) · Chemical Society Reviews · doi:10.1039/b821324k · Cited by 734
Tunable Rigidity of (Polymeric Core)–(Lipid Shell) Nanoparticles for Regulated Cellular Uptake
Sun, J., Zhang, L., Wang, J., Feng, Q., Liu, D., Yin, Q., Xu, D., Wei, Y., Ding, B., Shi, X., et al. (2015) · Advanced Materials · doi:10.1002/adma.201404788 · Cited by 486
Metadata
- Authors
- Shum, H. C., Kim, J.-W., & Weitz, D. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-06-25
- Volume
- 130
- Issue
- 29
- Pages
- 9543-9549
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1996130114
- Cited by
- 445
- References
- 2
- FWCI
- 15.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shum, H. C., Kim, J.-W., & Weitz, D. A. (2008). Microfluidic Fabrication of Monodisperse Biocompatible and Biodegradable Polymersomes with Controlled Permeability. Journal of the American Chemical Society. https://doi.org/10.1021/ja802157y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
