Direct Inhibition of Hypoxia-Inducible Transcription Factor Complex with Designed Dimeric Epidithiodiketopiperazine

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

Angiogenesis in cancer and other diseases

Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784

Hypoxia in cancer: significance and impact on clinical outcome

Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240

Glycolysis inhibition for anticancer treatment

Pelicano, H., Martin, D. S., Xu, R., & Huang, P. (2006) · Oncogene · doi:10.1038/sj.onc.1209597 · Cited by 1,546

Cancer's Molecular Sweet Tooth and the Warburg Effect

Kim, J., & Dang, C. V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1501 · Cited by 1,233

Transcription factors as targets for cancer therapy

Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194

HIF-1α pathway: role, regulation and intervention for cancer therapy

Masoud, G. N., & Li, W. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.05.007 · Cited by 1,871

2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products

Borthwick, A. D. (2012) · Chemical Reviews · doi:10.1021/cr200398y · Cited by 883

Protein Lysine Acetylation by p300/CBP

Rabbitts, B. M., & Cole, P. A. (2015) · Chemical Reviews · doi:10.1021/cr500452k · Cited by 640

Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition

Wang, F., Marshall, C. B., & Ikura, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1254-4 · Cited by 317

Pharmacologic Targeting of Hypoxia-Inducible Factors

Semenza, G. L. (2019) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021637 · Cited by 288

The transcription factor FOXM1 is a cellular target of the natural product thiostrepton

Hegde, N. S., Sanders, D. A., Rodriguez, R., & Balasubramanian, S. (2011) · Nature Chemistry · doi:10.1038/nchem.1114 · Cited by 278

Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

Zhao, Y., Xiong, W., Li, C., Zhao, R., Lu, H., Song, S., Zhou, Y., Hu, Y., Shi, B., & Ge, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01652-9 · Cited by 275

A complex task? Direct modulation of transcription factors with small molecules

Koehler, A. N. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.03.022 · Cited by 189

Enantioselective Total Synthesis of (+)-Gliocladine C: Convergent Construction of Cyclotryptamine-Fused Polyoxopiperazines and a General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors

DeLorbe, J. E., Jabri, S. Y., Mennen, S. M., Overman, L. E., & Zhang, F. (2011) · Journal of the American Chemical Society · doi:10.1021/ja201789v · Cited by 169

Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer

Singh, D. P., Arora, R., Kaur, P., Singh, B., Mannan, R., & Arora, S. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0190-2 · Cited by 171

Epidithiodioxopiperazines. occurrence, synthesis and biogenesis

Welch, T. R., & Williams, R. M. (2014) · Natural Product Reports · doi:10.1039/c3np70097f · Cited by 140

Inhibition of Hypoxia Inducible Factor 1—Transcription Coactivator Interaction by a Hydrogen Bond Surrogate α-Helix

Henchey, L. K., Kushal, S., Dubey, R., Chapman, R. N., Olenyuk, B. Z., & Arora, P. S. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9082864 · Cited by 136

In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

Lao, B. B., Grishagin, I. V., Mesallati, H., Brewer, T. F., Olenyuk, B. Z., & Arora, P. S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402393111 · Cited by 116

Concise total synthesis of (+)-gliocladins B and C

Boyer, N. C., & Movassaghi, M. (2012) · Chemical Science · doi:10.1039/c2sc20270k · Cited by 115

The tumour microenvironment as an integrated framework to understand cancer biology

Burgos‐Panadero, R., Lucantoni, F., Gamero‐Sandemetrio, E., de la Cruz‐Merino, L., Álvaro, T., & Noguera, R. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.07.010 · Cited by 106

Cytotoxic Metabolites from the Antarctic Psychrophilic Fungus Oidiodendron truncatum

Li, L., Li, D., Luan, Y., Gu, Q., & Zhu, T. (2012) · Journal of Natural Products · doi:10.1021/np3000443 · Cited by 105

Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

Andersen, A. P., Moreira, J. M. A., & Pedersen, S. F. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0098 · Cited by 105

Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

Kushal, S., Lao, B. B., Henchey, L. K., Dubey, R., Mesallati, H., Traaseth, N. J., Olenyuk, B. Z., & Arora, P. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312473110 · Cited by 103

Cyclometalated Ruthenium(II) Anthraquinone Complexes Exhibit Strong Anticancer Activity in Hypoxic Tumor Cells

Zeng, L., Chen, Y., Huang, H., Wang, J., Zhao, D., Ji, L., & Chao, H. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201502154 · Cited by 94

General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors: Enantioselective Total Syntheses of (+)- and (−)-Gliocladine C, (+)-Leptosin D, (+)-T988C, (+)-Bionectin A, and (+)-Gliocladin A

DeLorbe, J. E., Horne, D. A., Jove, R., Mennen, S. M., Nam, S., Zhang, F., & Overman, L. E. (2013) · Journal of the American Chemical Society · doi:10.1021/ja400315y · Cited by 91

Synthesis and anticancer activity of epipolythiodiketopiperazine alkaloids

Boyer, N. C., Morrison, K. C., Kim, J., Hergenrother, P. J., & Movassaghi, M. (2013) · Chemical Science · doi:10.1039/c3sc50174d · Cited by 83

Epipolythiodiketopiperazine Alkaloids: Total Syntheses and Biological Activities

Iwasa, E., Hamashima, Y., & Sodeoka, M. (2011) · Israel Journal of Chemistry · doi:10.1002/ijch.201100012 · Cited by 64

Crosstalk between Hypoxia and Extracellular Matrix in the Tumor Microenvironment in Breast Cancer

Dekker, Y., Dévédec, S. E. L., Danen, E. H. J., & Liu, Q. (2022) · Genes · doi:10.3390/genes13091585 · Cited by 66

Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications

Li, Z., You, Q., & Zhang, X. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01596 · Cited by 64

Suppression of Tumor Growth by Designed Dimeric Epidithiodiketopiperazine Targeting Hypoxia-Inducible Transcription Factor Complex

Dubey, R., Levin, M. D., Szabó, L., László, C., Kushal, S., Singh, J. B., Oh, P., Schnitzer, J. E., & Olenyuk, B. Z. (2013) · Journal of the American Chemical Society · doi:10.1021/ja400805b · Cited by 58

On the Histone Lysine Methyltransferase Activity of Fungal Metabolite Chaetocin

Cherblanc, F., Chapman, K. L., Reid, J., Borg, A. J., Sundriyal, S., Alcázar‐Fuoli, L., Bignell, E., Demetriades, M., Schofield, C. J., DiMaggio, P. A., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm401063r · Cited by 56

A Novel Cell-Permeable, Selective, and Noncompetitive Inhibitor of KAT3 Histone Acetyltransferases from a Combined Molecular Pruning/Classical Isosterism Approach

Milite, C., Feoli, A., Sasaki, K., Pietra, V. L., Balzano, A. L., Marinelli, L., Mai, A., Novellino, E., Castellano, S., Tosco, A., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm5019687 · Cited by 56

Action Sites and Clinical Application of HIF-1α Inhibitors

Xu, R., Wang, F., Yang, H., & Wang, Z. (2022) · Molecules · doi:10.3390/molecules27113426 · Cited by 59

Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II)

Jayatunga, M. K. P., Thompson, S., McKee, T. C., Chan, M. C., Reece, K. M., Hardy, A., Sekirnik, R., Seden, P. T., Cook, K. M., McMahon, J. B., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.06.006 · Cited by 45

Enantioselective organocatalytic α-sulfenylation of substituted diketopiperazines

Polaske, N. W., Dubey, R., Nichol, G. S., & Olenyuk, B. Z. (2009) · Tetrahedron Asymmetry · doi:10.1016/j.tetasy.2009.10.037 · Cited by 42

Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α

Chan, S. T. S., Patel, P., Ransom, T. R., Henrich, C. J., McKee, T. C., Goey, A. K. L., Cook, K. M., Figg, W. D., McMahon, J. B., Schnermann, M. J., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b02156 · Cited by 41

Transcriptional Switches: Chemical Approaches to Gene Regulation

Lee, L. W., & Mapp, A. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.075044 · Cited by 41

Advances in inhibition of protein-protein interactions targeting hypoxia-inducible factor-1 for cancer therapy

Li, J., Xi, W., Li, X., Sun, H., & Li, Y. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.01.042 · Cited by 41

Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression

Satija, S., Kaur, H., Tambuwala, M. M., Sharma, P., Vyas, M., Khurana, N., Sharma, N., Bakshi, H. A., Charbe, N. B., Zacconi, F. C. M., et al. (2021) · Current Molecular Pharmacology · doi:10.2174/1874467214666210120154929 · Cited by 40

Tricyclic analogues of epidithiodioxopiperazine alkaloids with promising in vitro and in vivo antitumor activity

Baumann, M., Dieskau, A. P., Loertscher, B. M., Walton, M. C., Nam, S., Xie, J., Horne, D. A., & Overman, L. E. (2015) · Chemical Science · doi:10.1039/c5sc01536g · Cited by 38

Helix Stabilized, Thermostable, and Protease-Resistant Self-Assembled Peptide Nanostructures as Potential Inhibitors of Protein–Protein Interactions

Jeong, W., Lee, M. S., & Lim, Y. (2013) · Biomacromolecules · doi:10.1021/bm400532y · Cited by 36

In vitro DNA-binding profile of transcription factors: methods and new insights

Wang, J., Lu, J., Gu, G., & Liu, Y. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0010 · Cited by 35

Protein–protein interactions in transcription: A fertile ground for helix mimetics

Guarracino, D. A., Bullock, B. N., & Arora, P. S. (2010) · Biopolymers · doi:10.1002/bip.21546 · Cited by 32

Natural epidithiodiketopiperazine alkaloids as potential anticancer agents: Recent mechanisms of action, structural modification, and synthetic strategies

Wang, L., Jiang, Q., Chen, S., Wang, S., Lu, J., Gao, X., Zhang, D., & Jin, X. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106642 · Cited by 26

Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300

Na, Y.-R., Han, K.-C., Park, H., & Yang, E. G. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.044 · Cited by 24

Cytotoxic Dimeric Epipolythiodiketopiperazines from the Ascomycetous Fungus Preussia typharum

Du, L., Robles, A. J., King, J. B., Mooberry, S. L., & Cichewicz, R. H. (2014) · Journal of Natural Products · doi:10.1021/np5002253 · Cited by 24

Mass spectrometry-based assay for the rapid detection of thiol-containing natural products

Capehart, S. L., & Carlson, E. E. (2016) · Chemical Communications · doi:10.1039/c6cc07111b · Cited by 26

Syntheses of Gliocladin C and Related Alkaloids

Hodges, T. R., Benjamin, N. M., & Martin, S. F. (2017) · Organic Letters · doi:10.1021/acs.orglett.7b00735 · Cited by 23

Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway

Wu, J., Zhang, Z., Zhang, L.-H., Jin, X., Ma, J., & Piao, H. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.12.060 · Cited by 23

Development of a route to chiral epidithiodioxopiperazine moieties and application to the asymmetric synthesis of (+)-hyalodendrin

Takeuchi, R., Shimokawa, J., & Fukuyama, T. (2014) · Chemical Science · doi:10.1039/c3sc53222d · Cited by 22

Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α–p300 interaction by a small molecule

Kwon, H. S., Kim, D.-R., Yang, E. G., Park, Y. K., Ahn, H.-C., Min, S.-J., & Ahn, D.-R. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.06.054 · Cited by 21

Role of HIF ‐1α in pathogenic mechanisms of keloids

Qiu, Z., Zhang, M., Zhang, W., Li, Z., Si, L., Long, X., Yu, N., & Wang, X. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15601 · Cited by 22

Total Syntheses of (+)‐T988 B and (+)‐T988 C through the AgNTf2‐Mediated Coupling of Bromopyrroloindoline with Indole

Sato, S., Hirayama, A., Ueda, H., & Tokuyama, H. (2016) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.201600474 · Cited by 19

Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics

Lee, L. W., Taylor, C. E., Desaulniers, J., Zhang, M., Højfeldt, J. W., Pan, Q., & Mapp, A. K. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.08.090 · Cited by 18

Rogersonins A and B, Imidazolone N-Oxide-Incorporating Indole Alkaloids from a verG Disruption Mutant of Clonostachys rogersoniana

Zhu, S., Ren, F., Guo, Z., Liu, J., Liu, X., Liu, G., & Che, Y. (2018) · Journal of Natural Products · doi:10.1021/acs.jnatprod.8b00851 · Cited by 17

CBP/p300: intramolecular and intermolecular regulations

Xue, Y., Wen, H., & Shi, X. (2018) · Frontiers in Biology · doi:10.1007/s11515-018-1502-6 · Cited by 18

Hypoxia-inducible transcription factors: architects of tumorigenesis and targets for anticancer drug discovery

McDermott, A., & Tavassoli, A. (2024) · Transcription · doi:10.1080/21541264.2024.2417475 · Cited by 18

Golgi apparatus targeted therapy in cancer: Are we there yet?

Lee, Z. Y., Lee, W. H., Lim, J. S., Ali, A. A. A., Loo, J. S. E., Wibowo, A., Mohammat, M. F., & Foo, J. B. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122868 · Cited by 15

Copper-catalyzed nitrene transfer/cyclization cascade to synthesize 3a-nitrogenous furoindolines and pyrroloindolines

Zhang, G., Peng, Y., Xue, J. W., Fan, Y.-H., & Deng, Q. (2019) · Organic Chemistry Frontiers · doi:10.1039/c9qo01124b · Cited by 15

A Common Precursor Approach to Structurally Diverse Natural Products: The Synthesis of the Core Structure of (±)‐Clausenamide and the Total Synthesis of (±)‐Hyalodendrin

Szulc, B. R., Sil, B. C., Ruiz, A. J., & Hilton, S. T. (2015) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201501256 · Cited by 14

Oxidative cyanation of 2-oxindoles: formal total synthesis of (±)-gliocladin C

Maity, A., Roy, A., Das, M. K., De, S., Naskar, M., & Bisai, A. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/c9ob02752a · Cited by 14

Inhibition of hypoxia‐inducible transcription factor complex with designed epipolythiodiketopiperazine

Kushal, S., Wang, H., László, C., Szabó, L., & Olenyuk, B. Z. (2010) · Biopolymers · doi:10.1002/bip.21550 · Cited by 12

Mivebresib alleviates systemic lupus erythematosus-associated diffuse alveolar hemorrhage via inhibiting infiltration of monocytes and M1 polarization of macrophages

He, X., Li, J., Hu, L., Du, P., Zhu, M., Wu, H., Zhao, M., & Lu, Q. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110305 · Cited by 14

Novel anticancer drug discovery strategies targeting hypoxia-inducible factors

Mustafa, M., Rashed, M., & Winum, J. (2024) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2024.2442739 · Cited by 11

Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy

Li, G., Shao, Y., Pan, Y., Li, Y., Wang, Y., Wang, L., Wang, X., Shao, K., Wang, S., Liu, N., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128338 · Cited by 11

Bispyrrolidinoindoline Epi(poly)thiodioxopiperazines (BPI-ETPs) and Simplified Mimetics: Structural Characterization, Bioactivities, and Total Synthesis

Martínez, C., García‐Domínguez, P., Álvarez, R., & de Lera, Á. R. (2022) · Molecules · doi:10.3390/molecules27217585 · Cited by 11

A benzotriazole-mediated route to protected marine-derived hetero-2,5-diketopiperazines containing proline

Nsengiyumva, O., Hamedzadeh, S., McDaniel, J., Macho, J. M., Simpson, G. G., Panda, S. S., Ha, K., Lebedyeva, I., Faidallah, H. M., AL-Mohammadi, M. M., et al. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00023h · Cited by 10

Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α

Shimizu, T., Takahashi, N., Huber, V. J., Asawa, Y., Ueda, H., Yoshimori, A., Muramatsu, Y., Seimiya, H., Kouji, H., Nakamura, H., et al. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115949 · Cited by 9

Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors

Li, G., Dong, H., Ma, Y., Shao, K., Li, Y., Wu, X., Wang, S., Shao, Y., & Zhao, W. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.06.017 · Cited by 9

Conformationally Assisted Lactamizations for the Synthesis of Symmetrical and Unsymmetrical Bis-2,5-diketopiperazines

Ha, K., Lebedyeva, I., Li, Z., Martin, K., Williams, B., Faby, E., Nasajpour, A., Pillai, G. G., Al-Youbi, A. O., & KATRITZKY, A. R. (2013) · The Journal of Organic Chemistry · doi:10.1021/jo401235k · Cited by 8

Assessing the importance and safety of hypoxia conditioning for patients with occupational pulmonary diseases: A recent clinical perspective

Zhang, X., Achkasov, E. E., Gavrikov, L. K., Yuchen, L., Zhang, C., Dudnik, E. N., Rumyantseva, O. I., Beeraka, N. M., & Glazachev, O. S. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117275 · Cited by 8

Synthesis and properties of an efficient tumor cells-interacting fluorescent probe derived from rhodamine B

Wang, T., Wang, C., Zheng, L., & He, H. (2014) · Journal of Luminescence · doi:10.1016/j.jlumin.2013.12.060 · Cited by 7

AgNTf2-Mediated Arylation of Bromopyrroloindolines

Tokuyama, H., Sato, S., Hirayama, A., Adachi, T., Kawauchi, D., & Ueda, H. (2017) · Heterocycles · doi:10.3987/com-17-13777 · Cited by 5

Synthesis of novel taspine diphenyl derivatives as fluorescence probes and inhibitors of breast cancer cell proliferation

He, H., Zhan, Y., Zhang, Y., Zhang, J., & He, L. (2011) · Luminescence · doi:10.1002/bio.1331 · Cited by 4

Histone Acetyltransferases: Targets and Inhibitors

Sbardella, G. (2019) · Methods and principles in medicinal chemistry · doi:10.1002/9783527809257.ch12 · Cited by 3

Anticancer Diketopiperazines from the Marine Fungus

Li, Z., & Hua, H. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_15 · Cited by 2

Natural Products as Inhibitors of Hypoxia-Inducible Factor-1

Nagle, D. G., & Zhou, Y. (2011) · CRC Press eBooks · doi:10.1201/b11196-8 · Cited by 1

Synthetic Studies on Heteropolycyclic Natural Products: Strategies via Novel Reactions and Reactivities

Shimokawa, J., & Fukuyama, T. (2017) · Journal of Synthetic Organic Chemistry Japan · doi:10.5059/yukigoseikyokaishi.75.1115 · Cited by 1

Double-stranded DNA microarray: principal, techniques and applications

Pan, Y., & Wang, J. (2013) · Hereditas (Beijing) · doi:10.3724/sp.j.1005.2013.00287 · Cited by 1

Role of Angiogenesis in the Pathogenesis of Arthritis: Potential Therapeutic Applications

Kiriakidis, S., & Paleolog, E. (2010) · Springer eBooks · doi:10.1007/978-90-481-9495-7_16

(+)-11,11′-Dideoxyverticillin A

Kim, J., & Movassaghi, M. (2012) · Springer eBooks · doi:10.1007/978-3-642-34065-9_9

The role of the CXCL12 – CXCR4 chemokine ligand – receptorinteraction in the metastasis of prostate cancer

Arya, M. (2011) · UCL Discovery (University College London)

Recent advances in applications of Friedel–Crafts reactions in total synthesis of alkaloids

Heravi, M. M., & Zadsirjan, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824021-2.00009-1

I. Synthesizing and Identifying Small Molecule Probes for Targeting Transcriptional Co-factors II. Design and Implementation of a Peer-Led Practical Research Ethics Module for Teaching Graduate Research Ethics.

Danowitz, A. M. (2011) · Deep Blue (University of Michigan)

BindingDB Entry 50009047: Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications.

BindingDB (2021) · UC San Diego · doi:10.7270/q2qf8x9v

BindingDB Entry 50043919: TBA

BindingDB (2014) · UC San Diego · doi:10.7270/q2ns0wdk

BindingDB Entry 50013546: Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy.

BindingDB (2022) · UC San Diego · doi:10.7270/q2p55s73

BindingDB Entry 50004666: Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α-p300 interaction by a small molecule.

BindingDB (2020) · UC San Diego · doi:10.7270/q2r49tm7

BindingDB Entry 50010309: Advances in inhibition of protein-protein interactions targeting hypoxia-inducible factor-1 for cancer therapy.

BindingDB (2021) · UC San Diego · doi:10.7270/q2qc072q

BindingDB Entry 50045786: A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach.

BindingDB (2016) · UC San Diego · doi:10.7270/q2736smp

BindingDB Entry 50008299: Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway.

BindingDB (2021) · UC San Diego · doi:10.7270/q2h70k6d

Suppression of Tumor Growth by Designed Dimeric Epidithiodiketopiperazine Targeting Hypoxia-Inducible Transcription Factor Complex

Dubey, R., Levin, M. D., Szabó, L., László, C., Kushal, S., Singh, J. B., Oh, P., Schnitzer, J. E., & Olenyuk, B. Z. (2013) · Journal of the American Chemical Society · doi:10.1021/ja400805b · Cited by 58

Inhibition of Hypoxia-Inducible Transcription by Disruption of p300-CH1-Zn2+-HIF-1a Complex with Designed Dimeric Epidithiodiketopiperazine

Makhoul, J. A. (2009) · UA Campus Repository (The University of Arizona)

Inhibition of hypoxia‐inducible transcription factor complex with designed epipolythiodiketopiperazine

Kushal, S., Wang, H., László, C., Szabó, L., & Olenyuk, B. Z. (2010) · Biopolymers · doi:10.1002/bip.21550 · Cited by 12

Abstract 1014: Novel selective HIF1 alpha inhibitor: Well tolerated with excellent efficacy in renal cell cancer xenograft studies

Dubey, R., Grishagin, I. V., Nagavarapu, U., Chenera, B., Gupta, S., & Olenyuk, B. Z. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-1014

Small molecule modulators of HIF1? signaling

Grishagin, I. V. (. (2014) · University of Southern California Digital Library · doi:10.25549/usctheses-c3-456649