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Cation-Triggered Drug Release from a Porous Zinc−Adeninate Metal−Organic Framework
Abstract
A porous anionic metal-organic framework, bio-MOF-1, constructed using adenine as a biomolecular building block is described. The porosity of this material is evaluated, its stability in biological buffers is studied, and its potential as a material for controlled drug release is investigated. Specifically, procainamide HCl is loaded into the pores of bio-MOF-1 using a simple cation exchange process. Exogenous cations from biological buffers are shown to affect the release of the adsorbed drug molecules.
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Citations
Cited by
Metal–Organic Frameworks for Separations
Li, J.-R., Sculley, J., & Zhou, H.-C. (2012) · Chemical Reviews · doi:10.1021/cr200190s · Cited by 6,323
BioMOFs: Metal–Organic Frameworks for Biological and Medical Applications
McKinlay, A. C., Morris, R. E., Horcajada, P., Férey, G., Gref, R., Couvreur, P., & Serre, C. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000048 · Cited by 1,256
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
MOF positioning technology and device fabrication
Falcaro, P., Ricco, R., Doherty, C. M., Liang, K., Hill, A. J., & Styles, M. J. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00089g · Cited by 710
Proton Transport in Metal–Organic Frameworks
Lim, D.-W., & Kitagawa, H. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00842 · Cited by 689
Metadata
- Authors
- An, J., Geib, S. J., & Rosi, N. L.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-06-02
- Volume
- 131
- Issue
- 24
- Pages
- 8376-8377
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2046741458
- Cited by
- 1,076
- References
- 0
- FWCI
- 30.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
