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Enzymatically Triggered Self-Assembly of Block Copolymers
Abstract
The polymerization of vinyl monomers with cleavable enzymatic substrates has been shown to lead to water-soluble double-hydrophilic block copolymers which, upon enzymatic activation of the diblock copolymers, become amphiphilic and undergo self-assembly into colloidal nanostructures. The ability to change the chemical and physical characteristics of polymeric materials by an enzymatic reaction opens the way for novel and exciting applications such as enzymatic-triggered activation of surfaces and formation of nanostructures in vivo in a highly controlled manner.
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Citations
Cited by
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 914
Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels
Hu, J., Zhang, G., & Liu, S. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35103j · Cited by 722
Mimicking the Cell: Bio-Inspired Functions of Supramolecular Assemblies
Tu, Y., Peng, F., Adawy, A., Men, Y., Abdelmohsen, L. K. E. A., & Wilson, D. A. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00344 · Cited by 316
Enzyme responsive materials: design strategies and future developments
Zelzer, M., Todd, S. J., Hirst, A. R., McDonald, T. O., & Ulijn, R. V. (2013) · Biomater. Sci. · doi:10.1039/c2bm00041e · Cited by 306
Zelzer, M., & Ulijn, R. V. (2010) · Chemical Society Reviews · doi:10.1039/c0cs00035c · Cited by 302
Metadata
- Authors
- Amir, R. J., Zhong, S., Pochan, D. J., & Hawker, C. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-09-09
- Volume
- 131
- Issue
- 39
- Pages
- 13949-13951
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1973209384
- Cited by
- 158
- References
- 0
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Enzymatically Triggered Self-Assembly of Block Copolymers. https://app.cochat.ai/papers/10.1021/ja9060917
- The paper
- Amir, R. J., Zhong, S., Pochan, D. J., & Hawker, C. J. (2009). Enzymatically Triggered Self-Assembly of Block Copolymers. Journal of the American Chemical Society. https://doi.org/10.1021/ja9060917
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.