The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Self-Assembly Synthesis, Tumor Cell Targeting, and Photothermal Capabilities of Antibody-Coated Indocyanine Green Nanocapsules
Open accessAbstract
New colloidal materials that can generate heat upon irradiation are being explored for photothermal therapy as a minimally invasive approach to cancer treatment. The near-infrared dye indocyanine green (ICG) could serve as a basis for such a material, but its encapsulation and subsequent use are difficult to carry out. We report the three-step room-temperature synthesis of approximately 120-nm capsules loaded with ICG within salt-cross-linked polyallylamine aggregates, and coated with antiepidermal growth factor receptor (anti-EGFR) antibodies for tumor cell targeting capability. We studied the synthesis conditions such as temperature and water dilution to control the capsule size and characterized the size distribution via dynamic light scattering and scanning electron microscopy. We further studied the specificity of tumor cell targeting using three carcinoma cell lines with different levels of EGFR expression and investigated the photothermal effects of ICG containing nanocapsules on EGFR-rich tumor cells. Significant thermal toxicity was observed for encapsulated ICG as compared to free ICG at 808 nm laser irradiation with radiant exposure of 6 W/cm(2). These results illustrate the ability to design a colloidal material with cell targeting and heat generating capabilities using noncovalent chemistry.
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EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent
Desai, M. P., Labhasetwar, V., Walter, E., Levy, R. J., & Amidon, G. L. (1997) · Pharmaceutical Research · doi:10.1023/a:1012126301290 · Cited by 858
Cited by
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Zha, Z., Yue, X., Ren, Q., & Dai, Z. (2013) · Advanced Materials · doi:10.1002/adma.201202211 · Cited by 746
Cai, W., Gao, H., Chu, C., Wang, X., Wang, J., Zhang, P., Lin, G., Li, W., Liu, G., & Chen, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11579 · Cited by 357
Zhang, S., Guo, W., Wei, J., Li, C., Liang, X.-J., & Yin, M. (2017) · ACS Nano · doi:10.1021/acsnano.6b08720 · Cited by 284
Abd Ellah, N. H., & Abouelmagd, S. A. (2017) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1213238 · Cited by 164
Metadata
- Authors
- Yu, J., Javier, D., Yaseen, M. A., Nitin, N., Richards-Kortum, R., Anvari, B., & Wong, M. S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-01-21
- Volume
- 132
- Issue
- 6
- Pages
- 1929-1938
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1991610238
- Cited by
- 312
- References
- 3
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Yu, J., Javier, D., Yaseen, M. A., Nitin, N., Richards-Kortum, R., Anvari, B., & Wong, M. S. (2010). Self-Assembly Synthesis, Tumor Cell Targeting, and Photothermal Capabilities of Antibody-Coated Indocyanine Green Nanocapsules. Journal of the American Chemical Society. https://doi.org/10.1021/ja908139y
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