The DOI matches its Crossref record.
Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc
Abstract
The rapid analysis of trace metal cations for environmental \nand biomedical applications is particularly demanding since it \nrequires the specific recognition of a particular element in the \npresence of numerous closely related species. While remarkable \nprogress has been achieved for inorganic analytes, such as Ca^(2+), there is still a significant need for the genesis of new fluorosensors. In light of the selectivity and avidity with which proteins bind divalent metal cations, we have chosen to use a polypeptide architecture as the framework for metal ion recognition.In addition, our ability to manipulate synthetic polypeptides allows the coordinated integration of fluorescent reporters for signal transduction within a metal-binding peptidyl construct. Herein we report the design, synthesis, and evaluation of a selective fluorescent chemosensor, sensitive to nanomolar \nconcentrations of Zn^(2+).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Recent Advances in Zinc Enzymology
Lipscomb, W. N., & Sträter, N. (1996) · Chemical Reviews · doi:10.1021/cr950042j · Cited by 1,366
Jiang, P., & Guo, Z. (2004) · Coordination Chemistry Reviews · doi:10.1016/j.cct.2003.10.013 · Cited by 989
Self-Assembled Nanoparticle Probes for Recognition and Detection of Biomolecules
Maxwell, D. J., Taylor, J. R., & Nie, S. (2002) · Journal of the American Chemical Society · doi:10.1021/ja025814p · Cited by 890
Komatsu, K., Urano, Y., Kojima, H., & Nagano, T. (2007) · Journal of the American Chemical Society · doi:10.1021/ja072432g · Cited by 542
Improvement and Biological Applications of Fluorescent Probes for Zinc, ZnAFs
Hirano, T., Kikuchi, K., Urano, Y., & Nagano, T. (2002) · Journal of the American Chemical Society · doi:10.1021/ja025567p · Cited by 422
Metadata
- Authors
- Walkup, G. K., & Imperiali, B.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 118
- Issue
- 12
- Pages
- 3053-3054
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2090117751
- Cited by
- 189
- References
- 0
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc. https://app.cochat.ai/papers/10.1021/ja9538501
- The paper
- Walkup, G. K., & Imperiali, B. (1996). Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc. Journal of the American Chemical Society. https://doi.org/10.1021/ja9538501
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
