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Self-Assembling Amphiphiles for Construction of Protein Molecular Architecture
Abstract
Peptide-amphiphiles with collagen-model head groups and dialkyl chain tails have been synthesized and shown to self-assemble into highly ordered polyPro II like triple-helical structures when dissolved in aqueous subphases. Evidence for this self-assembly process has been obtained from (a) compression of stable peptide-amphiphile monolayers to molecular areas comparable with triple-helical areas, (b) circular dichroism spectra and melting curves characteristic of triple-helices, and (c) two-dimensional NMR spectra indicative of stable triple-helical structure at low temperatures and melted triple-helices at high temperatures. The thermal stability of the collagen-like structure in the peptide-amphiphile is substantially higher (Δ T m = 15−20 °C) than that of peptides without lipidation. The assembly process driven by the hydrophobic tail may provide a general method for creating well-defined protein molecular architecture using a minimalist peptide-based approach.
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Cited by
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Sackmann, E., & Tanaka, M. (2000) · Trends in Biotechnology · doi:10.1016/s0167-7799(99)01412-2 · Cited by 417
Structure of Polyelectrolyte Brushes in the Presence of Multivalent Counterions
Yu, J., Mao, J., Yuan, G., Satija, S., Jiang, Z., Chen, W., & Tirrell, M. (2016) · Macromolecules · doi:10.1021/acs.macromol.6b01064 · Cited by 115
Self-citationBagheri, M., Nikolenko, H., Arasteh, S., Rezaei, N., Behzadi, M., Dathe, M., & Hancock, R. E. W. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c04336 · Cited by 31
Metadata
- Authors
- Yu, Y.-C., Berndt, P., Tirrell, M., & Fields, G. B.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 1996-01-01
- Volume
- 118
- Issue
- 50
- Pages
- 12515-12520
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2055628427
- Cited by
- 265
- References
- 0
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, Y.-C., Berndt, P., Tirrell, M., & Fields, G. B. (1996). Self-Assembling Amphiphiles for Construction of Protein Molecular Architecture. Journal of the American Chemical Society. https://doi.org/10.1021/ja9627656
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