TF-PROTACs Enable Targeted Degradation of Transcription Factors
Liu, Jing, Chen, He, Kaniskan, H. Ümit, Xie, Ling, Chen, Xian, Jin, Jian, Wei, Wenyi·2021·Journal of the American Chemical Society
Cited by (251)
Items 201–251 of 251
- The importance of controls in targeted protein degradation: Determining mechanismBrianna Hill-Payne, Sebastian Dilones, George M. Burslem · 2022 · Methods in enzymology on CD-ROM/Methods in enzymology
- High Mobility Group A1 Chromatin Keys: Unlocking the Genome During MPN ProgressionLinda M S Resar, Li Luo · 2025 · International Journal of Molecular Sciences
- PROTACs: Opportunities and Challenges Ahead in the Field of Drug DiscoveryAnish Kizhakkekkara Vadukoot · 2022 · International Journal of Medicine and Public Health
- Targeted i6A-RNA degradation through sequential Fluorination-Azidation and Click reaction with imidazole-based probesYuyang Guo, Xiaoqian Chen, Youfang Gan, Yuanyuan Li, Rui Wang · 2024 · Bioorganic & Medicinal Chemistry Letters
- The First‐In‐Class Deubiquitinase‐Targeting Chimera Stabilizes and Activates cGASZhijie Deng, Li Chen, Chao Qian, Jing Liu, Qiong Di Wu, Xiangyang Song, Yan Xiong, Zhen Wang, Xiaoping Hu, Hiroyuki Inuzuka et al. · 2024 · Angewandte Chemie
- Functionalized DNA secondary structures and nanostructures for specific protein modificationsBauke Albada · 2024 · Trends in Biochemical Sciences
- Design, synthesis and evaluation of pyrrolobenzodiazepine (PBD)-based PROTAC conjugates for the selective degradation of the NF-κB RelA/p65 subunitPeiqin Jin, Md. Mahbub Hasan, Andrea G. S. Pepper, Simon A. Mitchell, Khondaker Miraz Rahman, Chris J. Pepper · 2025 · RSC Medicinal Chemistry
- Proteolysis Targeting Chimera (PROTACs) in Cancer: From Molecular Mechanisms to Therapeutic OpportunitiesJing Yang, Qing Qiao, Na Lin, Miaomiao Niu, Lin Su, Boshu Yin · 2025 · Journal of Biochemical and Molecular Toxicology
- Engineered anchoring aptamers induce relocalization and functional inactivation of transcription factorsNeng Ling, Hui Wu, Yibin Zhang, Shuang Yao, Fangyu Liu, X. H. Tang, Tiantian Xie, Yijun Yuan, Xianhua Wei, Jing Dai et al. · 2026 · Science Advances
- Indirect ubiquitination independent of endogenous ubiquitination machinery for targeted protein degradationTakafumi Furuhata, Kazuki Yoshida, 藤田 凌嘉, Jotaro Miyamoto, Chiharu Moriyama, Tokiha Masuda-Ozawa, Hikaru Tsuchiya, Yasushi Saeki, Akimitsu Okamoto · 2026 · Communications Chemistry
- Arylidene-Thiazoldione Scaffold Acts as the E3 Ligand of DCAF11 for PROTAC DesignJinyi Liang, Yuyang Liu, Man Zhao, Lu Chen, Jiajie Qin, Wenjing Ma, Yue Wang, Haiqiang Wu, Ruilin Tian, Tianzi Wei et al. · 2026 · Journal of Medicinal Chemistry
- Accelerating the Discovery of Targeted Protein Degraders: Advances in Synthetic Methodologies and Screening TacticsBaoli Ding, Xiaotong Chen, Yulu Chen, Ji Cao, Bo Yang, Li Jiang, Cheng‐Liang Zhu · 2026 · Chemistry - A European Journal
- Bifunctional proximity-inducing strategies for targeted and programmable post-translational modificationsSadiya Tanga, Pallabi Das, Tuhin Baran Samoi, Arpita Hota, Arkadeep Karmakar, Basudeb Maji · 2026 · Advanced Drug Delivery Reviews
- PAX3::FOXO1-Targeting PROTAC Induces Myogenic Differentiation of Fusion-Positive Rhabdomyosarcoma CellsNikola Knoll, Kayra Somay, Purushottam Babu Tiwari, Emre Deniz, Jeffrey S. S. K. Formen, Isabel Frye, Eryn Nelson, Christian Wolf, Jeffrey A. Toretsky, Aykut Üren · 2026 · Cancers
- State‐of‐the‐Art Nrf2 Inhibitors: Therapeutic Opportunities in Non‐Cancer DiseasesEmil G. Ayala‐Cosme, Deborah J. Yang, Kyara Vences, Lindsey O. Davis, Matteo Borgini · 2024 · ChemMedChem
- Membrane‐Bounded Intracellular E3 Ubiquitin Ligase‐Targeting Chimeras (MembTACs) for Targeted Membrane Protein DegradationMengwu Mo, Feiyu Wang, Huimin Zhang, Ying Zhang, Chaoyong James Yang, Jinbiao Shang, Zhi Zhu · 2025 · Angewandte Chemie
- GRHL3 specifically initiated by the TP63 transcription factor promotes the metastasis of squamous cell carcinogenesisHanyu Bai, Xiaojian Wei, Yan Xi, Sisi Wei, Suli Dai, Dachi Wang, Yongxian Xue, Debnarayan Jana, Feng Gao, Wei Zhou et al. · 2025 · Cellular Signalling
- WITHDRAWN: Targeted protein degradation: A promising approach for cancer treatmentMuhammad Zafar Irshad Khan, Adila Nazli, Iffat Naz, Dildar Khan, Ihsan‐ul Haq, Jianzhong Chen · 2023 · Journal of Pharmaceutical Analysis · Retracted
- Targeting Transcription Factors for DegradationDirk H. Trauner, Matthew McLarney DiCairano · 2021 · Synfacts
- O bi namo ma ronga isi go Galelaka / ditulis Etha Yosafat ; diindonesiakan Robinon IpolYosafat Etha · 1985
- E2F1 activation by oncogenic FLT3 internal tandem duplication in regulating purine metabolism in acute myeloid leukaemiaFeihu Chen, Ziyao Ou, Ke Wang, Wenwen Shen, Ge Deng, Yayun Xu, Longfei Wang, Zhuoyan Zai, Yian Ling, Tao Zhang et al. · 2022 · Research Square
- The Future of Heterobifunctional Compounds: PROTACs and BeyondGeorge M. Burslem · 2022 · Wiley eBooks
- New Therapeutic Chemical Modalities: Compositions, Modes-of-action, and Drug DiscoveryEric Valeur · 2023 · Royal Society of Chemistry eBooks
- Structural Considerations and Chemistry of PROTACsAbhishek Wahi, Hemant R. Jadhav, Shikha Thakur, Sushma Dev, Priyanka Mohanty, Priti Jain · 2024 · Springer eBooks
- Computational modelling of aggressive B-cell lymphomaEleanor S. Jayawant, Aimilia Vareli, Andrea G. S. Pepper, Chris J. Pepper, Fabio A. Simoes, Simon A. Mitchell · 2025 · Biochemical Society Transactions
- Degradation of G‐Quadruplex‐Binding Proteins by G4L‐PROTAC via Quaternary Complex FormationRena Nohara, Yuma Tanaya, Mohammad Jafar Sheikhi, Pratiksha Chaudhary, Grinsun Sharma, Hanbin Mao, Kazuo Nagasawa, Masayuki Tera · 2025 · Angewandte Chemie
- PROTAC-mediated regulation of programmed cell death: From molecular mechanisms to therapeutic breakthroughsHangqi Huang, Aoli Deng, Feifan Pan, Yajuan Lu, Lulu Chen, Jinghao Cao, Qin Tang, Yingchao Liu, Yunyi Wu, Jing Du et al. · 2026 · The Innovation
- Nucleoside-ATTEC Conjugates for Targeting Inhibition of HIV Replication and InfectionXiaofeng Liao, Kaifu Zhang, Chu Wang, Mengmeng Liu, Jinsong Ren, Xiaogang Qu · 2026 · Journal of Medicinal Chemistry
- Towards the long-term, conditional and tractable disruption of Notch3 signaling in zebrafish neural stem and progenitor cellsMathilde Chouly · 2024
- Anticancer, Antitumor, and Antioxidant Microbial Lipids: Mechanism of Action, Production, and Clinical ApplicationMorteza Nadeb, Seyed Soheil Aghaei, Tahereh Komeili-Movahed, Hamed Afkhami · 2026 · Oxidative Medicine and Cellular Longevity
- HOXD10 promotes hepatocellular carcinoma progression by enhancing m6A methylation and activating the PI3K/AKT/mTOR pathway秦承东, Xinyi Gao, Siyuan Liu, Jiejie Hu, Lihong Hu, Chao Hu, Yang Yu, De-Ning Ma · 2026 · Journal of Translational Medicine
- Mapping Scientific Landscapes and Therapeutic Innovations of Targeted Protein Degradation: A Scientometric ReviewChong Li, Xiang-Xiu Wang, An-Qi He, Tianjie Bao, Wei-Hua Zhuang, Cheng-Qi He, Yong-Hong Yang · 2026 · Pharmaceutics
- The Diverse Roles of the MEF2 Transcription Factor Family in Tumor Progression and Emerging Therapeutic OpportunitiesYanyan Chen, Jingni Zhu, Jinghang Qian, Sheng Li, Yang Liu · 2026 · Biomedicines
- Targeted protein degradation: mechanistic diversity, therapeutic expansion, and clinical translationCaiyu Wang, Zhibin Guo, Yufei Liu, Qichao Gao, Qing Wang, Yi Liu, Yujiao Liu · 2026 · International Journal of Pharmaceutics
- Mechanobiology and Molecular Regulation of Periodontal Tissue Remodeling During Orthodontic Tooth Movement: From Periodontal Phenotype to Precision Orthodontics—A Narrative ReviewBartłomiej Górski, Edyta Kalina, Marcin Derwich · 2026 · International Journal of Molecular Sciences
- PROTAC as a Potential Toolbox for the Discovery of New Targets and DrugsMengjun Ma, Xiaolei Meng, Chong Qin · 2026 · Handbook of experimental pharmacology
- Branched DNA Nanoplatform-Based Multivalent PROTACs for Tumor Microenvironment-Responsive Degradation of Telomere-Binding Proteins in Tumor TherapyHanyin Zhu, Xintong Li, Hong Wang, Huarui Liu, Dandan Li, Changping Yang, Baoquan Ding, Jianbing Liu · 2026 · Nano Letters
- A mini-review of the molecular mechanisms, mutational landscape, and therapeutic opportunities of TWIST1 in oncologyBruno Ricardo Barreto Pires, Gerson Moura Ferreira, Eliana S. F. W. Abdelhay · 2026 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Chemically Induced Proximity for Targeted Protein O- GlcNAcylationBowen Ma, Tongyang Xu, Zhihao Guo, Wai‐Lung Ng · 2026 · Accounts of Chemical Research
- Protein degraders targeting JAK/STAT3 signaling pathway are emerging therapeutic modalities for human cancersXinyu Feng, Nanjing Li, Xiaorong Chen, Xinyue Cao, Jingling Dai, Shaoquan Xiong, Zhu Yuan · 2026 · Biochemical Pharmacology
- Self‐Reporting Hierarchical DNA Nanoplatform for Tumor Cell‐Selective Senescence Modulation and Immune RemodelingWenya Dang, Jun Da, Jun Cao, Haolan Hu, Yuqi Xie, Lu Yu, Lu Wu, Linlin Wang, Jili Li, Yanlan Liu · 2026 · Small Methods
- Centromere-Targeting Chimeras for Combating Cancer Drug ResistanceDingpeng Zhang, Zhen Wang, William W. Feng, Wenyun Zhang, Xutong Xue, Yan Xiong, Xing Gao, Hiroyuki Inuzuka, Jeanelle Tsai, Jiaqi Li et al. · 2026 · Journal of Medicinal Chemistry
- BindingDB Entry 50020161: Advances of bioorthogonal coupling reactions in drug development.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50016839: VHL-based PROTACs as potential therapeutic agents: Recent progress and perspectives.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50017503: Solid-Phase Synthesis of Cereblon-Recruiting Selective Histone Deacetylase 6 Degraders (HDAC6 PROTACs) with Antileukemic Activity.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50016515: Nucleic-Acid-Based Targeted Degradation in Drug Discovery.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50016429: Emerging targeted protein degradation tools for innovative drug discovery: From classical PROTACs to the novel and beyond.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50021731: Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50023360: PROTAC technology: From drug development to probe technology for target deconvolution.BindingDB · 2026 · UC San Diego
- BindingDB Entry 50020717: A beginner's guide to current synthetic linker strategies towards VHL-recruiting PROTACs.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50021132: Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders.BindingDB · 2025 · UC San Diego