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Label-Free Surface-Enhanced Raman Spectroscopy Detection of DNA with Single-Base Sensitivity
Abstract
Direct, label-free detection of unmodified DNA is a great challenge for DNA analyses. Surface-enhanced Raman spectroscopy (SERS) is a promising tool for DNA analyses by providing intrinsic chemical information with a high sensitivity. To address the irreproducibility in SERS analysis that hampers reliable DNA detection, we used iodide-modified Ag nanoparticles to obtain highly reproducible SERS signals of single- and double-strand DNA in aqueous solutions close to physiological conditions. The phosphate backbone signal was used as an internal standard to calibrate the absolute signal of each base for a more reliable determination of the DNA structure, which has not been achieved before. Clear identification of DNA with single-base sensitivity and the observation of a hybridization event have been demonstrated.
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Cited by
Raman Techniques: Fundamentals and Frontiers
Jones, R. R., Hooper, D. C., Zhang, L., Wolverson, D., & Valev, V. K. (2019) · Nanoscale Research Letters · doi:10.1186/s11671-019-3039-2 · Cited by 804
Fundamental understanding and applications of plasmon-enhanced Raman spectroscopy
Wang, X., Huang, S.-C., Hu, S., Yan, S., & Ren, B. (2020) · Nature Reviews Physics · doi:10.1038/s42254-020-0171-y · Cited by 689
Self-citationFan, M., Andrade, G. F. S., & Brolo, A. G. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.11.049 · Cited by 533
Multiplex in vitro detection using SERS
Laing, S., Gracie, K., & Faulds, K. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00644a · Cited by 361
Ngo, H. T., Gandra, N., Fales, A. M., Taylor, S. M., & Vo-Dinh, T. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.01.073 · Cited by 135
Metadata
- Authors
- Xu, L.-J., Lei, Z.-C., Li, J., Zong, C., Yang, C. J., & Ren, B.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-04-14
- Volume
- 137
- Issue
- 15
- Pages
- 5149-5154
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1981818407
- Cited by
- 456
- References
- 0
- FWCI
- 15.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xu, L.-J., Lei, Z.-C., Li, J., Zong, C., Yang, C. J., & Ren, B. (2015). Label-Free Surface-Enhanced Raman Spectroscopy Detection of DNA with Single-Base Sensitivity. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5b01426
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