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1,2,4-Triazines Are Versatile Bioorthogonal Reagents
Abstract
A new class of bioorthogonal reagents, 1,2,4-triazines, is described. These scaffolds are stable in biological media and capable of robust reactivity with trans-cyclooctene (TCO). The enhanced stability of the triazine scaffold enabled its direct use in recombinant protein production. The triazine-TCO reaction can also be used in tandem with other bioorthogonal cycloaddition reactions. These features fill current voids in the bioorthogonal toolkit.
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Cited by
Scinto, S. L., Bilodeau, D. A., Hincapie, R., Lee, W., Nguyen, S. S., Xu, M., am Ende, C. W., Finn, M. G., Lang, K., Lin, Q., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00028-z · Cited by 592
Self-citationContemporary approaches to site-selective protein modification
Hoyt, E. A., Cal, P. M. S. D., Oliveira, B. L., & Bernardes, G. J. L. (2019) · Nature Reviews Chemistry · doi:10.1038/s41570-019-0079-1 · Cited by 537
Bioorthogonal Chemistry and Its Applications
Bird, R. E., Lemmel, S. A., Yu, X., & Zhou, Q. A. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.1c00461 · Cited by 409
Recent progress in non-native nucleic acid modifications
McKenzie, L. K., El-Khoury, R., Thorpe, J. D., Damha, M. J., & Hollenstein, M. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01430c · Cited by 300
Chen, Z., Chen, M., Cheng, Y., Kowada, T., Xie, J., Zheng, X., & Rao, J. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201913314 · Cited by 71
Metadata
- Authors
- Kamber, D. N., Liang, Y., Blizzard, R. J., Liu, F., Mehl, R. A., Houk, K. N., & Prescher, J. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-06-25
- Volume
- 137
- Issue
- 26
- Pages
- 8388-8391
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2410801480
- Cited by
- 162
- References
- 0
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kamber, D. N., Liang, Y., Blizzard, R. J., Liu, F., Mehl, R. A., Houk, K. N., & Prescher, J. A. (2015). 1,2,4-Triazines Are Versatile Bioorthogonal Reagents. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5b05100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
