Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

Resnick, Efrat, Bradley, Anthony, Gan, Jinrui, Douangamath, Alice, Krojer, Tobias, Sethi, Ritika, Geurink, Paul P., Aimon, Anthony +26 more·2019·Journal of the American Chemical Society

Cited by (349)

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  12. Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments
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  16. Chemoproteomic Characterization of GPX4 Covalent Ligands and Targeted Degradation
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  17. First-in-Class Covalent Inhibitors of PFKFB3: Discovery and Characterization in PDAC Models
    Alessandra Fiore, Antônio Scarano, Giulia Antonini, Alexandra Ioana Corfu, Lea Sicuro, Serena Faggiano, Adriana Celesia, Chiara Tesoriero, Raffaella Pacchiana, Andrea Vettori et al. · 2026 · Journal of Medicinal Chemistry
  18. Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C-terminal Hydrolase L3
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  19. Chemical Space Exploration of a Database of Covalent Binders in the PDB
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  20. A FRET-Based Assay for Assessing Covalent Warhead Reactivity
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  21. Harnessing Collective Electrophilic Reactivity on Gold Nanoparticles Toward Versatile Target Identification
    Shione Kamoshita, Kaori Sakurai · 2026 · ChemistryEurope
  22. Machine learning-guided discovery of covalent sortase A inhibitors targeting MRSA virulence
    Xu-Liang Xu, Ti‐Ti Ying, Xiao-wen Wu, Yun-Jun Chen, Gang‐Ao Hu, Yu-Tian Guan, Shi-yi Liu, He Wang, Mohamed Seif, Mahmoud Emam et al. · 2026 · European Journal of Medicinal Chemistry
  23. On-resin Heck coupling enables small-molecule ligand discovery with covalent peptide-encoded libraries
    Ching-Pei Hsu, Michael Desgagné, Simon L. Rössler, Nathalie M. Grob, Charlotte E. Farquhar, Andrei Loas, Zena D. Jensvold, Hannah T. Baddock, Matthew A. Bratkowski, Aaron H. Nile et al. · 2026 · Chemical Science
  24. Leveraging Protein Dynamics for Selective Inhibition of Threonyl‐tRNA Synthetase by Obafluorin Analogs
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  25. Chemoproteomics in covalent cancer drug discovery
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  27. BindingDB Entry 50003388: Mechanisms and inhibitors of nicotinamide
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  30. BindingDB Entry 50013925: Discovery of selective fragment-sized immunoproteasome inhibitors.
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  31. BindingDB Entry 50022754: Covalent Inhibitors of S100A4 Block the Formation of a Pro-Metastasis Non-Muscle Myosin 2A Complex.
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  32. BindingDB Entry 50019872: Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes.
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  33. BindingDB Entry 11549: Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
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  34. BindingDB Entry 50016555: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor.
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  35. BindingDB Entry 50020975: Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1.
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  36. BindingDB Entry 50015871: Advanced approaches of developing targeted covalent drugs.
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  37. BindingDB Entry 50019640: Discovery of α-Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein.
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  38. BindingDB Entry 50015862: Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
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  39. BindingDB Entry 50018422: The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors.
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  40. BindingDB Entry 50009450: Discovery and optimization of covalent Bcl-xL antagonists.
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  41. BindingDB Entry 50023340: Size-Dependent Target Engagement of Covalent Probes.
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  42. BindingDB Entry 50013007: Irreversible inhibition of BoNT/A protease: proximity-driven reactivity contingent upon a bifunctional approach.
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  43. BindingDB Entry 50021912: Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story.
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  44. BindingDB Entry 50012178: Fragment-to-Lead Medicinal Chemistry Publications in 2019.
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  45. BindingDB Entry 50017299: -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction.
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  46. BindingDB Entry 50019939: Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.
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  47. BindingDB Entry 50019075: Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors.
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  48. BindingDB Entry 50020618: Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads.
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  49. BindingDB Entry 50023188: Innovative design and potential applications of covalent strategy in drug discovery.
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