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A Piperidine Amide Extracted from Piper longum L. Fruit Shows Activity against Aedes aegypti Mosquito Larvae
Abstract
Mosquito larvicidal activity of Piper longum fruit-derived materials against the fourth-instar larvae of Aedes aegypti was examined. A crude methanol extract of P. longum fruits was found to be active against the larvae, and the hexane fraction of the methanol extract showed a strong larvicidal activity of 100% mortality. The biologically active component of P. longum fruits was characterized as pipernonaline by spectroscopic analyses. The LC(50) value of pipernonaline was 0.25 mg/L. The toxicity of pipernonaline is comparable to that of pirimiphos-methyl as a mosquito larvicide. In tests with available components derived from P. longum, no activity was observed with piperettine, piperine, or piperlongumine.
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Cited by
A review of botanical phytochemicals with mosquitocidal potential
Shaalan, E. A.-S., Canyon, D., Younes, M. W. F., Abdel-Wahab, H., & Mansour, A.-H. (2005) · Environment International · doi:10.1016/j.envint.2005.03.003 · Cited by 621
Overview of the therapeutic potential of piplartine (piperlongumine)
Bezerra, D. P., Pessoa, C., de Moraes, M. O., Saker-Neto, N., Silveira, E. R., & Costa-Lotufo, L. V. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.12.003 · Cited by 324
Senthil-Nathan, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01591 · Cited by 266
Yadav, V., Krishnan, A., & Vohora, D. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112255 · Cited by 196
Metadata
- Authors
- Yang, Y.-C., Lee, S.-G., Lee, H.-K., Kim, M.-K., Lee, S.-H., & Lee, H.-S.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-05-18
- Volume
- 50
- Issue
- 13
- Pages
- 3765-3767
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1970360320
- Cited by
- 282
- References
- 0
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Piperidine Amide Extracted from Piper longum L. Fruit Shows Activity against Aedes aegypti Mosquito Larvae. https://app.cochat.ai/papers/10.1021/jf011708f
- The paper
- Yang, Y.-C., Lee, S.-G., Lee, H.-K., Kim, M.-K., Lee, S.-H., & Lee, H.-S. (2002). A Piperidine Amide Extracted from Piper longum L. Fruit Shows Activity against Aedes aegypti Mosquito Larvae. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf011708f
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
