Antioxidant Effect of Ferulic Acid in Isolated Membranes and Intact Cells: Synergistic Interactions with α-Tocopherol, β-Carotene, and Ascorbic Acid
Abstract
Although an antioxidant mechanism has been involved in the beneficial effects of ferulic acid in human diseases, there are few reports on the antioxidant properties of this compound in isolated membranes and intact cells. Here, we evaluated the ability of ferulic acid in inhibiting lipid peroxidation in rat liver microsomal membranes and reactive oxygen species production in NIH-3T3 fibroblasts, induced by both tert-BOOH and AAPH. We also compared its antioxidant efficiency with that of other antioxidants, such as alpha-tocopherol, beta-carotene, and ascorbic acid, added alone or in combination. Ferulic acid acted as a potent antioxidant in our models, being more effective in protecting from tert-BOOH than from AAPH. Moreover, the compound was the most effective among the antioxidants tested. Synergistic interactions were observed when the compound was used in combination with the other antioxidants, suggesting that they can cooperate in preserving physiological integrity of cells exposed to free radicals.
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Ferulic acid is a potent antioxidant with synergistic interactions with ascorbic acid.
“Ferulic acid is a potent antioxidant with synergistic interactions with ascorbic acid (Trombino et al, 2004).”
From Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin (2005) · cites this paper as Trombino et al, 2004
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Ferulic Acid Stabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin
Lin, F.-H., Lin, J.-Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Angelica Selim, M., Monteiro-Riviere, N. A., Grichnik, J. M., Zielinski, J., & Pinnell, S. R. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23768.x · Cited by 365 · see citing works
Micelle-nanogel platform for ferulic acid ocular delivery
Grimaudo, M. A., Amato, G., Carbone, C., Diaz-Rodriguez, P., Musumeci, T., Concheiro, A., Alvarez-Lorenzo, C., & Puglisi, G. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118986 · Cited by 63 · see citing works
- Authors
- Trombino, S., Serini, S., Di Nicuolo, F., Celleno, L., Andò, S., Picci, N., Calviello, G., & Palozza, P.
- Affiliations
- University of Calabria (IT)
- Department of Pharmaceutical Sciences, University of Calabria, 87030 Arcavacata di Rende, Cosenza, Italy, Institute of General Pathology, Catholic University, Lgo F. vito, 1, 00168, Rome, Italy, Cosmetological Universitary Center, Catholic University, Lgo F. vito, 1, 00168 Rome, Italy, and Department of Cell Biology, University of Calabria 87030 Arcavacata di Rende, Cosenza, Italy
- Corresponding author
- Palozza, Paola
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-03-20
- Volume
- 52
- Issue
- 8
- Pages
- 2411-2420
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1965593343
- Cited by
- 159
- References
- 0
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 15
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- ferulic acid, antioxidant activity, lipid peroxidation, reactive oxygen species, tert-butyl hydroperoxide, AAPH, alpha-tocopherol, beta-carotene, vitamin C, liver microsomal membranes, NIH3T3 cells, free radicals
- MeSH terms
- Animals, Antioxidants, Ascorbic Acid, Coumaric Acids, Drug Synergism, Fibroblasts, Intracellular Membranes, Microsomes, Liver, Lipid Peroxidation, Rats, Wistar, Reactive Oxygen Species, beta Carotene, alpha-Tocopherol, NIH 3T3 Cells, Mice, Rats
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