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HPLC-MSn Analysis of Phenolic Compounds and Purine Alkaloids in Green and Black Tea
Abstract
Tea is a complex mixture containing a range of compounds from simple phenolics to complex thearubigins, many of which have well-recognized antioxidant properties. This paper describes the application of high-performance liquid chromatography-mass spectrometry (HPLC-MS(n)) methods for the rapid and routine analysis of more than 30 phenolics in tea. Green and black tea infusions were injected directly onto a reversed phase HPLC column, and the phenolics eluted using two different mobile phase gradients, one optimized to resolve catechin derivatives and the other, flavonols and theaflavins. Compounds, identified on the basis of their retention time, absorbance spectrum, and MS fragmentation pattern, included (+)-catechin, (-)-epicatechin, theaflavin and their various gallate derivatives, quercetin and kaempferol mono-, di-, and triglycosides, quinic acid esters of gallic acid and hydroxycinnamates, and the purine alkaloids, caffeine and theobromine.
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Cited by
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Self-citationKaempferol and inflammation: from chemistry to medicine
Devi, K. P., Malar, D. S., Nabavi, S. F., Sureda, A., Xiao, J., Nabavi, S. M., & Daglia, M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.002 · Cited by 619
The chemistry and biotransformation of tea constituents
Sang, S., Lambert, J. D., Ho, C.-T., & Yang, C. S. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.02.007 · Cited by 492
Determination of the Chemical Composition of Tea by Chromatographic Methods: A Review
Yashin, A. Y., Nemzer, B. V., Combet, E., & Yashin, Y. I. (2015) · Journal of Food Research · doi:10.5539/jfr.v4n3p56 · Cited by 100
Umeda, M., Tominaga, T., Kozuma, K., Kitazawa, H., Furushima, D., Hibi, M., & Yamada, H. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02681-2 · Cited by 31
Metadata
- Authors
- Del Rio, D., Stewart, A. J., Mullen, W., Burns, J., Lean, M. E. J., Brighenti, F., & Crozier, A.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-04-27
- Volume
- 52
- Issue
- 10
- Pages
- 2807-2815
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1997111661
- Cited by
- 437
- References
- 0
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
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