The DOI matches its Crossref record.
Azaphilones, Furanoisophthalides, and Amino Acids from the Extracts of Monascus pilosus-Fermented Rice (Red-Mold Rice) and Their Chemopreventive Effects
Abstract
Six azaphilones, monascin ( 1 ), ankaflavin ( 2 ), rubropunctatin ( 3 ), monascorburin ( 4 ), rubropunctamine ( 5 ), and monascorburamine ( 6 ), two furanoisophthalides, xanthomonasin A ( 7 ) and xanthomonasin B ( 8 ), and two amino acids, (+)-monascumic acid ( 9 ) and (−)-monascumic acid ( 10 ), isolated from the extracts of Monascus pilosus -fermented rice (red-mold rice) were evaluated for their inhibitory effects on 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, on the induction of Epstein−Barr virus early antigen (EBV-EA) by TPA in Raji cells, and on the activation of (±)-( E )-methyl-2[( E )-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor. Among the compounds tested, seven compounds ( 1 − 6 and 10 ) on TPA-induced inflammation, and six compounds ( 1, 3 − 5, 9, and 10 ) on EBV-EA activation, exhibited potent inhibitory effects. All of the compounds tested showed moderate inhibitory effects on NOR 1 activation. Keywords: Monascus pilosus; red-mold rice; azaphilones; furanoisophthalides; amino acids; TPA-induced ear edema; antitumor-promoter; Epstein−Barr virus early antigen
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Azaphilones: Chemistry and Biology
Gao, J.-M., Yang, S.-X., & Qin, J.-C. (2013) · Chemical Reviews · doi:10.1021/cr300402y · Cited by 409
Feng, Y., Shao, Y., & Chen, F. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4504-3 · Cited by 341
Wang, L., Groβe, T., Stevens, H., Brinkhoff, T., Simon, M., Liang, L., Bitzer, J., Bach, G., Zeeck, A., Tokuda, H., et al. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0370-1 · Cited by 15
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Metadata
- Authors
- Akihisa, T., Tokuda, H., Yasukawa, K., Ukiya, M., Kiyota, A., Sakamoto, N., Suzuki, T., Tanabe, N., & Nishino, H.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-01-14
- Volume
- 53
- Issue
- 3
- Pages
- 562-565
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2008201503
- Cited by
- 201
- References
- 0
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
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