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Isolation and Characterization of the Lignans, Isolariciresinol and Pinoresinol, in Flaxseed Meal
Abstract
The isolation and characterization of the lignans, isolariciresinol, pinoresinol, secoisolariciresinol, and matairesinol, potent phytoestrogens, from flaxseed meal are described. This is the first report of isolariciresinol and pinoresinol being detected in a food. The extraction method selected combined the removal of the lignan glycosides from the plant matrix with an alcoholic solvent system, followed by acid hydrolysis to release the aglycons. A reversed-phase high-performance liquid chromatography with diode array detection system was used for initial separation and detection of the lignans at 280 nm in the acid-hydrolyzed methanolic extract. Lignan trimethylsilyl ether derivatives were characterized by gas chromatography/mass spectrometry. Secoisolariciresinol is the major lignan in flaxseed; isolariciresinol, pinoresinol, and matairesinol were identified as minor lignan components.
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Cited by
Polyphenols: Extraction Methods, Antioxidative Action, Bioavailability and Anticarcinogenic Effects
Brglez Mojzer, E., Knez Hrnčič, M., Škerget, M., Knez, Ž., & Bren, U. (2016) · Molecules · doi:10.3390/molecules21070901 · Cited by 1,096
Heinonen, S., Nurmi, T., Liukkonen, K., Poutanen, K., Wähälä, K., Deyama, T., Nishibe, S., & Adlercreutz, H. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010038a · Cited by 522
Touré, A., & Xueming, X. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2009.00105.x · Cited by 406
Metadata
- Authors
- Meagher, L. P., Beecher, G. R., Flanagan, V. P., & Li, B. W.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1999-07-22
- Volume
- 47
- Issue
- 8
- Pages
- 3173-3180
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1969688621
- Cited by
- 203
- References
- 0
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Isolation and Characterization of the Lignans, Isolariciresinol and Pinoresinol, in Flaxseed Meal. https://app.cochat.ai/papers/10.1021/jf981359y
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- Meagher, L. P., Beecher, G. R., Flanagan, V. P., & Li, B. W. (1999). Isolation and Characterization of the Lignans, Isolariciresinol and Pinoresinol, in Flaxseed Meal. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf981359y
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