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IAM chromatography: an in vitro screen for predicting drug membrane permeability
Abstract
Fluid cell membranes are the main barrier to drug absorption when diffusion limits uptake. Immobilized artificial membranes (IAMs) are solid phase models of fluid membranes that predicted oral drug absorption in mice for a homologous set of cephalosporins. IAMs also predicted drug permeability through Caco-2 cells. Since drug permeability in Caco-2 cells is known to correlate with the oral absorption of drugs in humans, IAMs may also model drug absorption in humans. IAM analysis is experimentally simple, and large-volume screening of experimental compounds for drug absorption is possible.
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Citations
Cited by
Artursson, P., Palm, K., & Luthman, K. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00128-9 · Cited by 1,543
Coexistence of passive and carrier-mediated processes in drug transport
Sugano, K., Kansy, M., Artursson, P., Avdeef, A., Bendels, S., Di, L., Ecker, G. F., Faller, B., Fischer, H., Gerebtzoff, G., et al. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3187 · Cited by 649
Physicochemical Profiling (Solubility, Permeability and Charge State)
Avdeef, A. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013395100 · Cited by 587
When poor solubility becomes an issue: From early stage to proof of concept
Stegemann, S., Leveiller, F., Franchi, D., de Jong, H., & Lindén, H. (2007) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2007.05.110 · Cited by 567
Caco-2 monolayers in experimental and theoretical predictions of drug transport
Artursson, P., Palm, K., & Luthman, K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.005 · Cited by 279
Metadata
- Authors
- Pidgeon, C., Ong, S., Liu, H., Qiu, X., Pidgeon, M., Dantzig, A. H., Munroe, J., Hornback, W. J., & Kasher, J. S.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1995-02
- Volume
- 38
- Issue
- 4
- Pages
- 590-594
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2087353625
- Cited by
- 267
- References
- 0
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pidgeon, C., Ong, S., Liu, H., Qiu, X., Pidgeon, M., Dantzig, A. H., Munroe, J., Hornback, W. J., & Kasher, J. S. (1995). IAM chromatography: an in vitro screen for predicting drug membrane permeability. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm00004a004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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