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Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR
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ADVERTISEMENT RETURN TO ISSUELetterNEXTIdentification of a Chemical Tool for the Orphan Nuclear Receptor FXRPatrick R. Maloney, Derek J. Parks, Curt D. Haffner, Adam M. Fivush, Gyan Chandra, Kelli D. Plunket, Katrina L. Creech, Linda B. Moore, Joan G. Wilson, Michael C. Lewis, Stacey A. Jones, and Timothy M. WillsonView Author Information Departments of Medicinal Chemistry, Molecular Biochemistry, Molecular Endocrinology, and Metabolic Diseases, Glaxo Wellcome Research & Development, Research Triangle Park, North Carolina 27709 Cite this: J. Med. Chem. 2000, 43, 16, 2971–2974Publication Date (Web):July 22, 2000Publication History Received18 May 2000Published online22 July 2000Published inissue 1 August 2000https://pubs.acs.org/doi/10.1021/jm0002127https://doi.org/10.1021/jm0002127rapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views3529Altmetric-Citations437LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Agonists,Anatomy,Aromatic compounds,Monomers,Receptors Get e-Alerts
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Citations
Cites
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636
Setchell, K. D., Schwarz, M., O'Connell, N. C., Lund, E. G., Davis, D. L., Lathe, R., Thompson, H. R., Weslie Tyson, R., Sokol, R. J., & Russell, D. W. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2962 · Cited by 375
Cited by
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940
Self-citationFibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865
Self-citationRole of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., & Staels, B. (2009) · Physiological Reviews · doi:10.1152/physrev.00010.2008 · Cited by 1,678
Targeting bile‐acid signalling for metabolic diseases
Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., & Schoonjans, K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2619 · Cited by 1,422
Metadata
- Authors
- Maloney, P. R., Parks, D. J., Haffner, C. D., Fivush, A. M., Chandra, G., Plunket, K. D., Creech, K. L., Moore, L. B., Wilson, J. G., Lewis, M. C., Jones, S. A., & Willson, T. M.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-07-22
- Volume
- 43
- Issue
- 16
- Pages
- 2971-2974
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2016716035
- Cited by
- 527
- References
- 2
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Maloney, P. R., Parks, D. J., Haffner, C. D., Fivush, A. M., Chandra, G., Plunket, K. D., Creech, K. L., Moore, L. B., Wilson, J. G., Lewis, M. C., Jones, S. A., & Willson, T. M. (2000). Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm0002127
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