The DOI matches its Crossref record.
Hypocholesterolemic activity of synthetic and natural tocotrienols.
Abstract
Tocotrienols are farnesylated benzopyran natural products that exhibit hypocholesterolemic activity in vitro and in vivo. The mechanism of their hypolipidemic action involves posttranscriptional suppression of HMG-CoA reductase by a process distinct from other known inhibitors of cholesterol biosynthesis. An efficient synthetic route to tocotrienols and their isolation from palm oil distillate using an improved procedure is presented. gamma-Tocotrienol exhibits a 30-fold greater activity toward cholesterol biosynthesis inhibition compared to alpha-tocotrienol in HepG2 cells in vitro. The synthetic (racemic) and natural (chiral) tocotrienols exhibit nearly identical cholesterol biosynthesis inhibition and HMG-CoA reductase suppression properties as demonstrated in vitro and in vivo.
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Cited by
Qureshi, A. A., Sami, S. A., Salser, W. A., & Khan, F. A. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00144-9 · Cited by 118
Self-citationMichihara, A., Ogawa, S., Kamizaki, Y., & Akasaki, K. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.1471 · Cited by 9
Metadata
- Authors
- Pearce, B. C., Parker, R. A., Deason, M. E., Qureshi, A. A., & Wright, J. J. K.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1992-10
- Volume
- 35
- Issue
- 20
- Pages
- 3595-3606
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1964867222
- Cited by
- 293
- References
- 0
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
