Mechanism and inhibition of cytochrome P-450 aromatase

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Items 101–200 of 320

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3. Aromatase inhibitors in breast cancer therapy
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4. Competitive product inhibition of aromatase by natural estrogens
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5. Design, synthesis and biochemical studies of new 7α-allylandrostanes as aromatase inhibitors
   Carla L. Varela, Cristina Amaral, Georgina Correia‐da‐Silva, Rui A. Carvalho, Natércia A. A. Teixeira, Saúl C. Costa, Fernanda M.F. Roleira, E. J. Tavares da Silva · 2013 · Steroids
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7. Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase Inhibitors
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8. Effect of Dentin Disinfection with 2% Chlorhexidine Gluconate and 0.3% Iodine on Dentin Bond Strength: Anin vitroStudy
   N Suma · 2017 · International Journal of Clinical Pediatric Dentistry
9. Metabolic Activation of trans-4-Hydroxy-2-nonenal, a Toxic Product of Membrane Lipid Peroxidation and Inhibitor of P450 Cytochromes
   Chung-Liang Kuo, Alfin D. N. Vaz, Minor J. Coon · 1997 · Journal of Biological Chemistry
10. Enzyme-activated inhibitors of steroidal hydroxylases
    J. O'Neal Johnston, C. Lee Wright, Gene W. Holbert · 1995 · The Journal of Steroid Biochemistry and Molecular Biology
11. Letrozole-stimulated endometrial preparation protocol is a superior alternative to hormone replacement treatment for frozen embryo transfer in women with polycystic ovary syndrome, a cohort study
    Xiaojuan Wang, Yuan Li, Hongzhuan Tan, Sufen Cai, Shujuan Ma, Yangqin Peng, Hui Guo, Xiaofeng Li, Yi Tang, Shunji Zhang et al. · 2023 · Reproductive Biology and Endocrinology
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13. Challenges and Considerations in Optimizing Ovarian Stimulation Protocols in Oncofertility Patients
    Kathryn D. Coyne, MacKenzie P. Purdy, Kathleen Oâ€TMLeary, Jerome L. Yaklic, Steven R. Lindheim, Leslie A. Appiah · 2014 · Frontiers in Public Health
14. Investigations on synthesis of indole based constrained mimetic scaffolds through 1,3-dipolar cycloadditions of the C-(3-indolyl)-N-phenylnitrone with a variety of olefinic and allenic dipolarophiles under microwave irradiation
    Surinderjit Singh Bhella, A.P.S. Pannu, Munusamy Elango · 2009 · Tetrahedron
15. Mechanism-based categorization of aromatase inhibitors: a potential discovery and screening tool
    Petko I. Petkov, Stanislav Temelkov, Daniel L. Villeneuve · 2009 · SAR and QSAR in environmental research
16. Insight into the binding interactions of CYP450 aromatase inhibitors with their target enzyme: a combined molecular docking and molecular dynamics study
    Roberta Galeazzi, Luca Massaccesi · 2011 · Journal of Molecular Modeling
17. Exemestane as First-Line Therapy in Postmenopausal Women With Recurrent or Metastatic Breast Cancer
    Stefan Glück · 2010 · American Journal of Clinical Oncology
18. RETRACTED ARTICLE: Clomiphene citrate or aromatase inhibitors combined with gonadotropins for superovulation in women undergoing intrauterine insemination: A prospective randomised trial
    Ahmed Badawy, Aboubakr Mohamed Elnashar, Mohamed Totongy · 2010 · Journal of Obstetrics and Gynaecology · Retracted
19. Antiestrogenic Action of Atrazine and its Major Metabolites in Vitro.
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20. Medical Approaches to Ovarian Stimulation for Infertility
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21. Evaluation of Antimicrobial Efficacy of various Intracanal Medicaments in Primary Teeth: Anin vivoStudy
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22. Steroids: reactions and partial synthesis
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23. Mechanism for aromatase inactivation by a suicide substrate, androst-4-ene-3,6,17-trione
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24. Clinical Cases in Oncofertility
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25. Crystal chemistry of some synthetic 2-oxa-steroids: conformation, packing motifs and isostructurality
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26. Ovarian Stimulation Is Safe and Effective for Patients with Gynecologic Cancer
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27. Structure–activity relationships of 2α-substituted androstenedione analogs as aromatase inhibitors and their aromatization reactions
    Mitsuteru Numazawa, Wakako Handa, Chie Hasegawa · 2005 · The Journal of Steroid Biochemistry and Molecular Biology
28. Effect of the aromatase inhibitor vorozole on estrogen and progesterone receptor content of rat mammary carcinomas induced by 1-methyl-1-nitrosourea
    Katrina K. Knott, John N. McGinley, Ronald A. Lubet · 2001 · Breast Cancer Research and Treatment
29. Novel 10β-aziridinyl steroids; inhibitors of aromatase
    Vincent C.O. Njar, Elam Safi, J. V. Silverton · 1993 · Journal of the Chemical Society Perkin Transactions 1
30. Selective inhibition of steriodogenic P450 enzymes: current status and future perspectives
    Rolf W. Hartmann · 1994 · European Journal of Pharmaceutical Sciences
31. Altered gene expression profile in chemically induced rat mammary adenocarcinomas and its modulation by an aromatase inhibitor
    Yian Wang, Lan Hu, Ruisheng Yao, Min Wang, Keith A. Crist, Clinton J. Grubbs, Gary L. Johanning, Ronald A. Lubet, Ming You · 2001 · Oncogene
32. Expeditious and convenient synthesis of pregnanes and its glycosides as potential anti-dyslipidemic and anti-oxidant agents
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33. 6α,7 ga-Cyclopropane derivatives of androst-4-ene: A novel class of competitive aromatase inhibitors
    Mitsuteru Numazawa, Ayako Mutsumi · 1991 · Biochemical and Biophysical Research Communications
34. A time-dependent inactivation of aromatase by 19-oxygenated androst-4-ene-3,6,17-triones
    Mitsuteru Numazawa, Ayako Mutsumi, Kumiko Hoshi · 1991 · The Journal of Steroid Biochemistry and Molecular Biology
35. Effect of Non‐Steroidal Aromatase Inhibitor on Blood Plasma Ovarian Steroid and Thyroid Hormones in Laying Hen (Gallus domesticus)
    Andrzej Sechman, Janusz Rząsa, H. Paczoska‐Eliasiewicz · 2003 · Zentralblatt für Veterinärmedizin Reihe A
36. Aromatase Inhibitors: Clinical Pharmacology and Therapeutic Implications in Breast Cancer
    N Pérez, Javier Borja · 1992 · Journal of International Medical Research
37. ‘Slow-binding’ sixth-ligand inhibitors of cytochrome P-450 aromatase. Studies with 19-thiomethyl- and 19-azido-androstenedione
    J. Neville Wright, G Slatcher, Muhammad Akhtar · 1991 · Biochemical Journal
38. Roles of Ferric Peroxide Anion Intermediates (Fe3+O2−, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model
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39. Pharmacophore-based virtual screening, molecular docking, and molecular dynamics investigation for the identification of novel, marine aromatase inhibitors
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40. Pharmacological and Non-Pharmacological Interventions for Polycystic Ovary Syndrome (PCOS) in Indian Women: A Systematic Review and Meta-Analysis
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41. Clinical and Radiographic Evaluation of Four Different Pulpotomy Agents in Primary Molars: A Longitudinal Study
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42. Elucidation of the biosynthetic pathways of boldenone in the equine testis
    Marjaana Viljanto, Andrew T. Kicman, Christopher J. Walker · 2019 · Steroids
43. 4-Oxygenated androst-5-en-17-ones and their 7-oxo derivatives as aromatase inhibitors
    Mitsuteru Numazawa, Mii Tachibana, Yoki Tateda · 1996 · The Journal of Steroid Biochemistry and Molecular Biology
44. 4 Inhibition of aromatase
    Lee Banting · 1996 · Progress in medicinal chemistry
45. Elucidating the role of androgen receptor in breast cancer
    Elgene Lim, Min Ni, Aditi Hazra · 2012 · Clinical Investigation
46. Lack of cross-resistance between non-steroidal and steroidal aromatase inhibitors in breast cancer patients: the potential role of the adipokine leptin
    Nazli Bahrami, Shakila Jabeen, Andliena Tahiri, Torill Sauer, Hilde Presterud Ødegård, Stephanie Beate Geisler, Berit Gravdehaug, Laurens Cornelus Reitsma, Knut Selsås, Vessela N. Kristensen et al. · 2021 · Breast Cancer Research and Treatment
47. A prospective double-blinded, randomized, placebo-controlled trial on the use of letrozole pretreatment with misoprostol for second-trimester medical abortion
    Vivian Chi Yan Lee, Oi Shan Tang, Ernest Hung Yu Ng, William S.B. Yeung, Pak Chung Ho · 2011 · Contraception
48. Novel approach to the synthesis of the aromatase inhibitor 4-hydroxyandrost-4-ene-3,17-dione (4-OHA)
    E. J. Tavares da Silva, Maria Luisa Sá e Melo, Andre ́S. Campos Neves · 1996 · Journal of the Chemical Society Perkin Transactions 1
49. 7α-Arylaliphatic androsta-1,4-diene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase
    Jill M. O'Reilly, Robert W. Brueggemeier · 1996 · The Journal of Steroid Biochemistry and Molecular Biology
50. Synthesis of 6α,7α- and 6β,7β-aziridinoandrost-4-ene-3,17-diones and related compounds: potential aromatase inhibitors
    Vincent C.O. Njar, Rolf W. Hartmann, Cecil Howard Robinson · 1995 · Journal of the Chemical Society Perkin Transactions 1
51. 19-oxygenations of 3-deoxy androgens, potent competitive inhibitors of estrogen biosynthesis, with human placental aromatase
    Mitsuteru Numazawa, Masao Nagaoka, Makoto Morio · 1999 · The Journal of Steroid Biochemistry and Molecular Biology
52. Effect of Casein Phosphopeptide–amorphous Calcium Phosphate and Calcium Sodium Phosphosilicate on Artificial Carious Lesions: Anin vitroStudy
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53. Studies directed toward a mechanistic evaluation of aromatase inhibition by androst-5-ene-7,17-dione
    Mitsuteru Numazawa, Mii Tachibana · 1997 · Steroids
54. Mesial Stripping of Mandibular Deciduous Canines for Correction of Permanent Lateral Incisors
    Yahya Baradaran Nakhjavani, Farid B Nakhjavani, Ahmad Jafari · 2017 · International Journal of Clinical Pediatric Dentistry
55. A time-dependent inactivation of aromatase by 19-substituted androst-4-ene-3,6,17-triones
    Mitsuteru Numazawa, Ayako Mutsumi, Naomi Asano · 1993 · Steroids
56. Synthesis and Evaluation of a Dimer of 2‐(4‐Pyridylmethyl)‐1‐Indanone as a Novel Nonsteroidal Aromatase Inhibitor
    R. Gupta, Dharam Paul Jindal, Birinder Jit · 2004 · Archiv der Pharmazie
57. The angular trifluoromethyl group at the steroidal AB ring junction
    Jean‐Claude Blazejewski, Frédéric Le Guyader, Claude Wakselman · 1992 · Tetrahedron Letters
58. A- or B-Ring-substituted derivatives of androst-4-ene-3,6,17-trione as aromatase inhibitors. Structure-activity relationships
    Mitsuteru Numazawa, Mii Tachibana · 1994 · Steroids
59. Probing the active site of aromatase with 2-methyl-substituted androstenedione analogs
    Mitsuteru Numazawa, Yoko Watari, Keiko Yamada · 2003 · Steroids
60. The angular trifluoromethyl group. Part 4. Synthesis of the 9,9,9-trifluoro analogue of the Wieland–Miescher ketone
    Jean‐Claude Blazejewski, Frédéric Le Guyader, Claude Wakselman · 1991 · Journal of the Chemical Society Perkin Transactions 1
61. Inhibition and inactivation of equine aromatase by steroidal and non-steroid al compounds. A comparison with human aromatase inhibition
    Safa Moslemi, Gilles‐Éric Séralini · 1997 · Journal of enzyme inhibition
62. Effects of letrozole on bone biomarkers and femur fracture in female rats
    Zafer Yönden, M. Aydin, Ergül Alçin, M. Halidun Keleştemur, Selim Kutlu, Bayram Yılmaz · 2009 · Journal of Physiology and Biochemistry
63. Studies on the catalytic function of aromatase: aromatization of 6-alkoxy-substituted androgens
    Mitsuteru Numazawa, Momoko Ando, Rika Zennyoji · 2002 · The Journal of Steroid Biochemistry and Molecular Biology
64. Bone metabolism and quality-of-life of postmenopausal women with invasive breast cancer receiving neoadjuvant hormonal therapy: Sub-analyses from celecoxib anti-aromatase neoadjuvant (CAAN) trial
    Louis W.C. Chow, Adrian YS Yip, William Chu, Wings T.Y. Loo, Masakazu Toi · 2011 · The Journal of Steroid Biochemistry and Molecular Biology
65. Low aromatase activity in microsomes from complete hydatidiform mole.
    Susana Genti‐Raimondi, Cecilia Álvarez, Luis C. Patrito · 1993 · The Journal of Clinical Endocrinology & Metabolism
66. Medicinal Chemistry of Steroids: Recent Developments
    Flip J. Zeelen · 1992 · Advances in Drug Research
67. Biochemistry and pharmacology of 7α-substituted androstenediones as aromatase inhibitors
    Robert W. Brueggemeier, Jill M. O'Reilly, Carl J. Lovely · 1997 · The Journal of Steroid Biochemistry and Molecular Biology
68. Structure-Activity Relationships of Estrogen Derivatives as Aromatase Inhibitors. Effects of Heterocyclic Substituents
    Mitsuteru Numazawa, Sachiko Komatsu, Takako Tominaga · 2008 · Chemical and Pharmaceutical Bulletin
69. Bioactive Compounds from the Genus Broussonetia
    Dongho Lee, Alan Douglas Kinghorn · 2003 · Studies in natural products chemistry
70. Substituted androstanes as aromatase inhibitors
    Inna S. Levina · 1998 · Russian Chemical Reviews
71. Synthesis of and chemical model reaction studies with 3-deoxyandrogens: evidence supporting a 2, 3-enolization hypothesis in human placental aromatase catalysis
    Soonsin S. Oh, Cecil Howard Robinson · 1994 · Journal of the Chemical Society Perkin Transactions 1
72. Improved Synthesis and Molecular Modeling of 4.BETA.,19-Dihydroxyandrost-5-en-17-one, an Excellent Inhibitor of Aromatase.
    Mitsuteru Numazawa, Keiko Yamada, Yoko Watari · 2002 · Chemical and Pharmaceutical Bulletin
73. Evaluation of 6,7-Aziridinyl Steroids and Related Compounds as Inhibitors of Aromatase (P-450arom)
    Vincent C.O. Njar, Gertrud L. Grün, Rolf W. Hartmann · 1995 · Journal of enzyme inhibition
74. The NEOLETEXE Trial: A Neoadjuvant Cross-Over Study Exploring the Lack of Cross Resistance Between Aromatase Inhibitors
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75. Aromatase inhibitors: Effect of ring A and ring B unsaturation on aromatase inhibition by 4-thiosubstituted derivatives of 4-androstene-3,17-dione
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77. Synthesis of 10β-(1′-azirinyl)estr-4-en-3,17-dione as an aromatase inhibitor
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79. Natural and synthetic flavonoid derivatives with potential antioxidant and anticancer activities
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80. Computational insights into inhibitory mechanism of azole compounds against human aromatase
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81. The effect of 7 days of letrozole pretreatment combined with misoprostol on the expression of progesterone receptor and apoptotic factors of placental and decidual tissues from first-trimester abortion: a randomized controlled trial
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83. Time-dependent aromatase inactivation by 4β,5β-epoxides of the natural substrate androstenedione and its 19-oxygenated analogs
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86. Ovulation Induction in Anovulatory Patients with Polycystic Ovary Syndrome
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87. The Mechanism of a P-450 Enzyme-Aromatase; a Molecular Modelling Perspective for the Removal of the C(19) Methyl and Aromatisation of the Steroid a Ring
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88. Structure-Activity Studies of Non-Steroidal Aromatase Inhibitors: The Crystal and Molecular Structures of CGS 16949A and CGS 18320B
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95. Aryltricyclospirodienones; novel steroid mimics as inhibitors of aromatase
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96. Synthesis of functionalized 1-vinylazoles by a novel wittig reaction of 1-acylazoles
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97. New Generation Aromatase Inhibitors in Breast Cancer
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98. Expedient synthesis of lactone analogues of formestane as new potential aromatase inhibitors
    E. J. Tavares da Silva, Maria Luisa Sá e Melo, Andre ́S. Campos Neves · 1997 · Journal of the Chemical Society Perkin Transactions 1
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100. Letrozole for ovulation induction
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