1-Benzyl-3-(5‘-hydroxymethyl-2‘-furyl)indazole (YC-1) Derivatives as Novel Inhibitors Against Sodium Nitroprusside-Induced Apoptosis
Abstract
Antiapoptotic agents based on 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock. We found that compound 22, 1-benzyl-3-(5'-methoxymethyl-2'-furyl)indazole (27), and 1-phenyl-3-(5'-hydroxymethyl-2'-furyl)indazole (23) were the most effective inhibitors of sodium nitroprusside-induced vascular smooth muscle cell apoptosis. These three compounds are proposed as potential therapeutic agents for the treatment of sepsis.
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YC-1 interacts with several non-HIF targets, complicating attribution of its biological effects solely to HIF inhibition.
“In addition, YC-1 is known to interact with several non-HIF targets, complicating attribution of its biological effects solely to HIF inhibition [405,406].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [405]
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HIF inhibition: Current strategies and clinical challenges
Więch-Walów, A., Bartoszewska, S., Barton, A., Czechowicz, P., Dudzik, J., Wielockx, B., Collawn, J. F., & Bartoszewski, R. (2026) · Redox biology · doi:10.1016/j.redox.2026.104220 · Cited by 3 · see citing works
“In addition, YC-1 is known to interact with several non-HIF targets, complicating attribution of its biological effects solely to HIF inhibition [405,406].”
- Authors
- Lien, J.-C., Lee, F.-Y., Huang, L.-J., Pan, S.-L., Guh, J.-H., Teng, C.-M., & Kuo, S.-C.
- Affiliations
- National Taiwan University (TW)
- Corresponding author
- Lien, Jin-Cherng
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-10-08
- Volume
- 45
- Issue
- 23
- Pages
- 4947-4949
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1975541406
- Cited by
- 26
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and pharmacological studies
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- anti-apoptotic agents, apoptosis inhibition, sodium nitroprusside, vascular smooth muscle cells, sepsis, septic shock, indazole derivatives
- MeSH terms
- Administration, Oral, Animals, Cells, Cultured, Indazoles, Muscle, Smooth, Vascular, Nitroprusside, Apoptosis, Sepsis, Nitric Oxide Donors, Enzyme Activators, Muscle Cells, Mice, Rats
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