The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification of a Novel Cardenolide (2‘ ‘-Oxovoruscharin) from Calotropis procera and the Hemisynthesis of Novel Derivatives Displaying Potent in Vitro Antitumor Activities and High in Vivo Tolerance: Structure−Activity Relationship Analyses
Open accessAbstract
Analysis of the methanolic extract of Calotropis procera root barks enabled the identification of a novel cardenolide (2''-oxovoruscharin) to be made. Of the 27 compounds that we hemisynthesized, one (23) exhibited a very interesting profile with respect to its hemisynthetic chemical yield, its in vitro antitumor activity, its in vitro inhibitory influence on the Na+/K+-ATPase activity, and its in vivo tolerance. Compound 23 displayed in vitro antitumor activity on a panel of 57 human cancer cell lines similar to taxol, and higher than SN-38 (the active metabolite of irinotecan), two of the most potent drugs used in hospitals to combat cancer.
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Stein (2000) · doi:10.1054/mehy.1999.0985 · Cited by 171
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Stenkvist, B. (1999) · Oncology Reports · doi:10.3892/or.6.3.493 · Cited by 160
Cited by
Cardiotonic steroids on the road to anti-cancer therapy
Mijatovic, T., Van Quaquebeke, E., Delest, B., Debeir, O., Darro, F., & Kiss, R. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.06.002 · Cited by 317
Self-citationAnticancer steroids: linking natural and semi-synthetic compounds
Salvador, J. A. R., Carvalho, J. F. S., Neves, M. A. C., Silvestre, S. M., Leitão, A. J., Silva, M. M. C., & Sá e Melo, M. L. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20082a · Cited by 276
Metadata
- Authors
- Van Quaquebeke, E., Simon, G., André, A., Dewelle, J., Yazidi, M. E., Bruyneel, F., Tuti, J., Nacoulma, O., Guissou, P., Decaestecker, C., Braekman, J.-C., Kiss, R., & Darro, F.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-01-19
- Volume
- 48
- Issue
- 3
- Pages
- 849-856
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2085753859
- Cited by
- 161
- References
- 2
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
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