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Novel Schiff Base Copper Complexes of Quinoline-2 Carboxaldehyde as Proteasome Inhibitors in Human Prostate Cancer Cells
Open accessAbstract
We report the synthesis of novel 1:1 Schiff base copper complexes of quinoline-2-carboxaldehyde showing dose-dependent, antiproliferative, and proapoptotic activity in PC-3 and LNCaP prostate cancer cells. We found that quinoline thiosemicarbazone 2 (FPA-137) was the most potent and inhibited proteosome activity in intact human prostate cancer PC-3 and LNCaP cells (IC50 of 4 and 3.2 microM, respectively) compared to clioquinol and pyrrolidine dithiocarbamate (IC50 of 10 and 20 microM), supporting the novelty of 2.
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Ubiquitin, proteasomes, and the regulation of intracellular protein degradation
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Self-citationProteasome Inhibition Measurements: Clinical Application
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Hydroxyurea Induces Site‐specific DNA Damage via Formation of Hydrogen Peroxide and Nitric Oxide
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Degola, F., Morcia, C., Bisceglie, F., Mussi, F., Tumino, G., Ghizzoni, R., Pelosi, G., Terzi, V., Buschini, A., Restivo, F. M., et al. (2015) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2015.02.009 · Cited by 46
Metadata
- Authors
- Adsule, S., Barve, V., Chen, D., Ahmed, F., Dou, Q. P., Padhye, S., & Sarkar, F. H.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-11-01
- Volume
- 49
- Issue
- 24
- Pages
- 7242-7246
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2061687864
- Cited by
- 334
- References
- 9
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Adsule, S., Barve, V., Chen, D., Ahmed, F., Dou, Q. P., Padhye, S., & Sarkar, F. H. (2006). Novel Schiff Base Copper Complexes of Quinoline-2 Carboxaldehyde as Proteasome Inhibitors in Human Prostate Cancer Cells. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm060712l
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