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Molecular Recognition of Protein Kinase Binding Pockets for Design of Potent and Selective Kinase Inhibitors
Abstract
ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTMolecular Recognition of Protein Kinase Binding Pockets for Design of Potent and Selective Kinase InhibitorsJeffrey Jie-Lou LiaoView Author Information TransTech Pharma, 4170 Mendenhall Oaks Parkway, High Point, North Carolina 27265, and Department of Chemistry, Duke University, Durham, North Carolina 27708 Cite this: J. Med. Chem. 2007, 50, 3, 409–424Publication Date (Web):January 10, 2007Publication History Received10 July 2006Published online10 January 2007Published inissue 8 February 2007https://pubs.acs.org/doi/10.1021/jm0608107https://doi.org/10.1021/jm0608107review-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views9361Altmetric-Citations417LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Adenine,Conformation,Inhibitors,Monomers,Peptides and proteins Get e-Alerts
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Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738
The specificities of protein kinase inhibitors: an update
BAIN, J., McLAUCHLAN, H., ELLIOTT, M., & COHEN, P. (2003) · Biochemical Journal · doi:10.1042/bj20021535 · Cited by 1,369
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Roskoski, R. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2015.10.021 · Cited by 886
Properties of FDA-approved small molecule protein kinase inhibitors
Roskoski, R. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.03.006 · Cited by 554
Halogen bonding (X‐bonding): A biological perspective
Scholfield, M. R., Zanden, C. M. V., Carter, M., & Ho, P. S. (2013) · Protein Science · doi:10.1002/pro.2201 · Cited by 451
Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization.
Okamoto, K., Ikemori-Kawada, M., Jestel, A., von König, K., Funahashi, Y., Matsushima, T., Tsuruoka, A., Inoue, A., & Matsui, J. (2015) · ACS Medicinal Chemistry Letters · doi:10.1021/ml500394m · Cited by 285
Properties of FDA-approved small molecule protein kinase inhibitors: A 2023 update
Roskoski, R. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2022.106552 · Cited by 273
Metadata
- Authors
- Liao, J. J.-L.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-01-10
- Volume
- 50
- Issue
- 3
- Pages
- 409-424
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2049885874
- Cited by
- 507
- References
- 4
- FWCI
- 49.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liao, J. J.-L. (2007). Molecular Recognition of Protein Kinase Binding Pockets for Design of Potent and Selective Kinase Inhibitors. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm0608107
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