On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses

Cites (275)

Items 201–258 of 258

1. Inhibition by barbituric acid and its derivatives of the enzymes in rat brain which participate in the synthesis of pyrimidine ribotides
   Barry W. Potvin, Harvey J. Stern, S. Randolph May, George F.M. Lam, Robert S. Krooth · 1978 · Biochemical Pharmacology
2. Detergent-dependent Kinetics of Truncated Plasmodium falciparumDihydroorotate Dehydrogenase
   Nicholas A. Malmquist, Jeffrey Baldwin, Margaret A. Phillips · 2007 · Journal of Biological Chemistry
3. Inhibitors of dihydroorotate dehydrogenase
   Douglas G. Batt · 1999 · Expert Opinion on Therapeutic Patents
4. Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors
   Udo Bauer, Fabrizio Giordanetto, Martin Bauer, Gavin O’Mahony, Kjell E. Johansson, Wolfgang Knecht, Judith Hartleib‐Geschwindner, Eva Töppner Carlsson, Cristofer Enroth · 2012 · Bioorganic & Medicinal Chemistry Letters
5. Thermodynamic Basis of Electron Transfer in Dihydroorotate Dehydrogenase B from Lactococcus lactis: Analysis by Potentiometry, EPR Spectroscopy, and ENDOR Spectroscopy
   Al-Walid A. Mohsen, Stephen E. J. Rigby, Kaj Frank Jensen, Andrew W. Munro, Nigel Shaun Scrutton · 2004 · Biochemistry
6. Leflunomide in dermatology
   Alan S. Boyd · 2011 · Journal of the American Academy of Dermatology
7. [9] Dihydroorotate dehydrogenase (Neurospora)
   Richard W. Miller · 1978 · Methods in enzymology on CD-ROM/Methods in enzymology
8. Biaryl analogues of teriflunomide as potent DHODH inhibitors
   Montse Erra, Imma Moreno, Jordi Sanahuja, Míriam Andrés, Raquel F. Reinoso, Estrella Lozoya, Pilar M. Pizcueta, Núria Godessart, Julio Cesar Castro-Palomino · 2011 · Bioorganic & Medicinal Chemistry Letters
9. Mechanistic studies on the bovine liver mitochondrial dihydroorotate dehydrogenase using kinetic deuterium isotope effects
   Victoria Hines, Michael Johnston · 1989 · Biochemistry
10. Biochemical Characterization of the Heteromeric Bacillus subtilis Dihydroorotate Dehydrogenase and Its Isolated Subunits
    Andrea Elise Kahler, F. S. NIELSEN, Robert L. Switzer · 1999 · Archives of Biochemistry and Biophysics
11. A sensitive, nonradiometric assay for dihydroorotic acid dehydrogenase using anion-exchange high-performance liquid chromatography
    Godefridus J. Peters, Emile J. Laurensse, Albert LEYVA, Herbert M. Pinedo · 1987 · Analytical Biochemistry
12. Dihydroorotate dehydrogenase fromSaccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues
    Elke Zameitat, Antonio J. Pierik, Kathleen Zocher, M. Löffler · 2007 · FEMS Yeast Research
13. Historical development of brequinar sodium as a new immunosuppressive drug for transplantation.
    Leonard Makowka, Frances A. Chapman, Donald V. Cramer · 1993 · PubMed
14. Kinetic and Structural Analysis of Mutant Escherichia coli Dihydroorotases: A Flexible Loop Stabilizes the Transition State,
    Mihwa Lee, Megan J. Maher, Richard Ian Christopherson, Jules Mitchell Guss · 2007 · Biochemistry
15. Purification of the Primary Dihydroorotate Dehydrogenase (Oxidase) from Rat Liver Mitochondria
    Henry Jay Forman, James Kennedy · 1977 · Preparative Biochemistry
16. The unique immunosuppressive activity of brequinar sodium.
    BRUCE D. JAFFEE, E A Jones, Scott E. Loveless, S F Chen · 1993 · PubMed
17. Phase I Safety and Pharmacokinetic Studies of Brequinar Sodium after Single Ascending Oral Doses in Stable Renal, Hepatic, and Cardiac Allograft Recipients
    Amita Joshi, Shang‐Ying P. King, Barbara Zając, Leonard Makowka, Linda S. Sher, Barry D. Kahan, Alan H. Menkis, CALVIN R. STILLER, Brigitte Schaefle, David M. Kornhauser · 1997 · The Journal of Clinical Pharmacology
18. Thiadiazolidinones: A new class of alanine racemase inhibitors with antimicrobial activity against methicillin-resistant Staphylococcus aureus
    Mihai Ciustea, Sara Mootien, Adriana E. Rosato, Oriana A. Perez, Pier Francesco Cirillo, Kacheong R. Yeung, Michel Ledizet, Michael H. Cynamon, Paul A. Aristoff, Raymond A. Koski et al. · 2011 · Biochemical Pharmacology
19. Sequence analysis of a Dictyostelium discoideum gene coding for an active dihydroorotate dehydrogenase in yeast
    Michel Jacquet, Monique Kalékine, Emmanuelle Boy‐Marcotte · 1985 · Biochimie
20. Structure-activity relationships (SAR) of some tetracyclic heterocycles related to the immunosuppressive agent brequinar sodium
    William J. Pitts, James W. Jetter, Donald J. P. Pinto, Michael J. Orwat, Douglas G. Batt, Susan R. Sherk, Joseph J. Petraitis, Irina C. Jacobson, Robert A. Copeland, Randine L. Dowling et al. · 1998 · Bioorganic & Medicinal Chemistry Letters
21. Role of Lys100 in Human Dihydroorotate Dehydrogenase: Mutagenesis Studies and Chemical Rescue by External Amines
    Wenjun Jiang, Gregory A. Locke, Mark R. Harpel, Robert A. Copeland, Jovita A. Marcinkeviciene · 2000 · Biochemistry
22. Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus lactis,
    Abigail E. Wolfe, Majbritt Thymark, Samuel Guy Gattis, Rebecca L. Fagan, Yu-Chen Hu, Eva Johansson, S. Arent, Sine Larsen, Bruce Allan Palfey · 2007 · Biochemistry
23. Laquinimod in multiple sclerosis
    Paul Steven Giacomini, Amit Bar‐Or · 2011 · Clinical Immunology
24. Proton Transfer from the C5-proR/proS Positions of l -Dihydroorotate: General-Base Catalysis, Isotope Effects, and Internal Return1
    Argyrides Argyrou, Michael W. Washabaugh · 1999 · Journal of the American Chemical Society
25. A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH
    Deborah Cowen, Paul T. P. Bedingfield, Glenn A. McConkey, Colin W. G. Fishwick, A. Peter Johnson · 2009 · Bioorganic & Medicinal Chemistry Letters
26. Novel immunosuppressive butenamides
    C.A. Axton, Michael E. J. Billingham, Paul M. Bishop, P. T. Gallagher, Terence A. Hicks, E Kitchen, Graham W. Mullier, W. Martin Owton, Mark G. Parry, Susan J. Scott et al. · 1992 · Journal of the Chemical Society Perkin Transactions 1
27. Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures
    Larry R. McLean, Ying Zhang, William J. Degnen, Jane Peppard, Dasha Cabel, Chao Zou, Joseph T. Tsay, Arun Subramaniam, Roy J. Vaz, Yi Li · 2010 · Bioorganic & Medicinal Chemistry Letters
28. Pyrazole Bioisosteres of Leflunomide as B-Cell Immunosuppressants for Xenotransplantation and Chronic Rejection: Scope and Limitations
    Christos Papageorgiou, Rainer Albert, Philipp Floersheim, Michel Lemaire, Francis Bitch, Hans-Peter Weber, Elsebeth Andersen, Valerie Hungerford, Max H. Schreier · 1998 · Journal of Medicinal Chemistry
29. Leflunomide's Bioactive Metabolite Has the Minimal Structural Requirements for the Efficient Inhibition of Human Dihydroorotate Dehydrogenase
    Christos Papageorgiou, Mauro G. M. Zurini, Hans-Peter Weber, Xaver Borer · 1997 · Bioorganic Chemistry
30. Leflunomide Analogues as Potential Antiinflammatory Agents.
    Wen‐Hsin Huang, Chiao‐Li Yang, An‐Rong Lee, Hui‐Fen Chiu · 2003 · Chemical and Pharmaceutical Bulletin
31. Leflunomide pharmacokinetics after single oral administration to dogs
    L. M. SINGER, Leah A. Cohn, Carol R. Reinero, Mark G. Papich · 2011 · Journal of Veterinary Pharmacology and Therapeutics
32. Disruption of the Proton Relay Network in the Class 2 Dihydroorotate Dehydrogenase fromEscherichia coli
    Rebecca L. Kow, Jonathan R. Whicher, Claudia A. McDonald, Bruce Allan Palfey, Rebecca L. Fagan · 2009 · Biochemistry
33. Immunosuppression With 4SC-101, a Novel Inhibitor of Dihydroorotate Dehydrogenase, in a Rat Model of Renal Transplantation
    Krisztina Rusai, Christoph Schmaderer, Marcus Baumann, Stefan Chmielewski, Ágnes Prókai, Éva Kis, Attila Jozsef Szabo, Johann Jakob Leban, R. Doblhofer, Aldo Ammendola et al. · 2012 · Transplantation
34. Synthesis and fungicidal activity of a series of novel aryloxylepidines
    Neil V Kirby, John F. Daeuble, L. Navelle Davis, Anna C. Hannum, Karin Hellwig, Lori K. Lawler, Marshall H. Parker, Mary E. Pieczko · 2001 · Pest Management Science
35. Antiviral Activity of Inhibitors of Pyrimidine De-Novo Biosynthesis
    Matthew Wachsman, Fayez M. Hamzeh, N. B. Assadi, Paul S. Lietman · 1996 · Antiviral chemistry & chemotherapy
36. Anti-arthritic effects of KF20444, a new immunosuppressive compound inhibiting dihydroorotate dehydrogenase, on rat collagen-induced arthritis
    Katsuya Kobayashi, A. Nakashima, H Nagata, Hiroshi Nakajima, Kensei Yamaguchi, S. Sato, I Miki · 2001 · Inflammation Research
37. Isoxazolylthioamides as potential immunosuppressants a combinatorial chemistry approach
    Rainer Albert, Hellmut Knecht, Elsebeth Andersen, Valerie Hungerford, Max H. Schreier, Christos Papageorgiou · 1998 · Bioorganic & Medicinal Chemistry Letters
38. Identification of a Novel Inhibitor (NSC 665564) of Dihydroorotate Dehydrogenase with a Potency Equivalent to Brequinar
    Emily S. Cleaveland, Daniel W. Zaharevitz, James A. Kelley, Kenneth D. Paull, David A. Cooney, Harry Ford · 1996 · Biochemical and Biophysical Research Communications
39. Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression.
    E A Neidhardt, Sandhya R. Punreddy, Jeremy E. McLean, Lizbeth Hedstrom, Trudy H. Grossman · 1999 · PubMed
40. Stereoselectivity in the enzymic oxidation and nonenzymic hydrogen-exchange reactions of dihydroorotate
    Loren D. Keys, Michael Johnston · 1985 · Journal of the American Chemical Society
41. Hydrogen Bonding Pathways in Human Dihydroorotate Dehydrogenase
    Yolanda A. Small, Vı́ctor Guallar, Alexander V. Soudackov, Sharon Hammes‐Schiffer · 2006 · The Journal of Physical Chemistry B
42. Latent inhibitors. Part 4. Irreversible inhibition of dihydro-orotate dehydrogenase by hydantoins derived from amino acids
    Ian G. Buntain, Colin J. Suckling, Hamish C. S. Wood · 1988 · Journal of the Chemical Society Perkin Transactions 1
43. Structure of the putative dihydroorotate dehydrogenase fromStreptococcus mutans
    Ying Liu, Zengqiang Gao, Chao-Pei Liu, Jian-Hua Xu, Lan-Fen Li, Chao-Neng Ji, Xiao‐Dong Su, Yuhui Dong · 2011 · Acta Crystallographica Section F Structural Biology and Crystallization Communications
44. Discovery and Characterization of Substituted Diphenyl Heterocyclic Compounds as Potent and Selective Inhibitors of Hepatitis C Virus Replication
    Peiyong Huang, Dane A. Goff, Qi Zhong Huang, Anthony D. Martinez, Xiang Ming Xu, Scott M. Crowder, Sarkiz D. Issakani, Emily Anderson, Ning Sheng, Philip Achacoso et al. · 2008 · Antimicrobial Agents and Chemotherapy
45. Preclinical Toxicity and Pharmacokinetics of the Bruton's Tyrosine Kinase-Targeting Anti-leukemic Drug Candidate, α-Cyano-β-Hydroxy-β-Methyl-N-(2,5-Dibromophenyl) Propenamide (LFM-A13)
    Fatih Mehmet Uckun, Heather Tibbies, Taracad K. Venkatachalam, Darin D. DuMez, Douglas H. Erbeck · 2011 · Arzneimittelforschung
46. Latent inhibitors. Part 6. Inhibition of dihydro-orotate dehydrogenase by substituted 5-benzylhydantoins
    Colin Howie, Colin J. Suckling, Hamish C. S. Wood · 1990 · Journal of the Chemical Society Perkin Transactions 1
47. Substrate Binding and Reactivity Are Not Linked: Grafting a Proton-Transfer Network into a Class 1A Dihydroorotate Dehydrogenase
    Claudia A. McDonald, Bruce Allan Palfey · 2011 · Biochemistry
48. Synthesis of β-hydroxy-propenamide derivatives and the inhibition of human dihydroorotate dehydrogenase
    Taek Hyeon Kim, Hye-Sun Na, Monika Löffler · 2003 · Archives of Pharmacal Research
49. FK778: New Cellular and Molecular Mechanisms of Action
    Sonja Schrepfer, T. Deuse, Friedrich Koch‐Nolte, Christian Detter, Hermann C. Reichenspurner · 2006 · Transplantation Proceedings
50. Biological activity and mode of action of some dihydroorotic and dihydroazaorotic acid derivatives.
    Jürgen Miersch, Konstantin Ch. Grancharov, Gerd‐Joachim Krauss, Nadejda Chr. Spassovska, G Karamanov, Liliana Maneva, Jordanka Mladenova, Evgeny V. Golovinsky · 1987 · PubMed
51. The Identification and Optimization of Oömycete Dihydroorotate Dehydrogenase Inhibitors as Fungicides
    Marshall H. Parker, Greg Durst, Anna C. Hannum, M. Henry, Lori K. Lawler, Amy J. Smith · 2001 · ACS symposium series
52. An N-(alkylcarbonyl)anthranilic acid derivative prolongs cardiac allograft survival synergistically with cyclosporine A in a high-responder rat model
    Jibing Chen, Junjie Xia, Bengt Axelsson, Ingela Fritzson, Henrik Ekberg, Marie Törngren, Zhongquan Qi · 2010 · Transplant Immunology
53. Synthesis and immunomodulating activity of condensed N-aryl-2-cyano-3-oxo-3-pyrazolyl-propanamides.
    Gianfederico Doria, A M Isetta, R. FERRECCIO, M Ferrari, Maria Chiara Fornasiero, Marcellino Tibolla, M Rossi, Orlando Carlini, P Motta, M. Magistrelli · 1991 · PubMed
54. Inhibition of cyclosporin-resistant B-cell antigen responses by pyrazoles: a tool for the identification of novel molecular mechanisms of B-cell activation
    Christos Papageorgiou, Rainer Albert, Elsebeth Andersen, Mauro G. M. Zurini, Valerie Hungerford, Philipp Floersheim, Max H. Schreier · 2001 · Transplantation Proceedings
55. ChemInform Abstract: Latent Inhibitors. Part 6. Inhibition of Dihydroorotate Dehydrogenase by Substituted 5‐Benzylhydantoins.
    Colin Howie, Colin J. Suckling, Hamish C. S. Wood · 1991 · ChemInform
56. ChemInform Abstract: Latent Inhibitors. Part 7. Inhibition of Dihydroorotate Dehydrogenase by Spirocyclopropanobarbiturates.
    W. Hamish Fraser, Colin J. Suckling, Hamish C. S. Wood · 1991 · ChemInform
57. Teriflunomide
    B. Boyd, J. Castañer · 2005 · Drugs of the Future
58. FK-778
    M. Cullell-Young, R.M. Castaner, P.A. Leeson · 2002 · Drugs of the Future