Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia
Kelly, Martha J., Pietranico-Cole, Sherrie, Larigan, J. Douglas, Haynes, Nancy-Ellen, Reynolds, Charles H., Scott, Nathan, Vermeulen, John, Dvorozniak, Mark +11 more·2014·Journal of Medicinal Chemistry
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- Prise en charge clinique et thérapeutique des hépatopathies stéatosiques associées à une dysfonction métabolique (MASLD)Anne Tailleux, Saı̈d Kamel · 2026 · Revue Francophone des Laboratoires
- [New ways in interdisciplinarity: internal medicine meets human genetics : When frequent conditions become rare and rare conditions become frequent].L. Möller, Ann-Kathrin Schörding, Frank J. Kaiser, M. Nöthen, E. Mack, A. Neubauer · 2026 · Innere Medizin
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- Influence du sexe dans la susceptibilité aux hépatopathies métaboliquesSarra Smati · 2019 · theses.fr (ABES)
- Estimation of rezdiffra (MGL-3196) by validated RP-HPLC approach in bulk material and pharmaceutical formulationMd. Abid Hasan, Raisa Tasnim Simran, Ejaj Sumit, Musfirat Tania, Maria Kibtia Ali · 2026 · Drug Development and Industrial Pharmacy
- Emerging metabolic hormone therapeutics for metabolic dysfunction-associated steatohepatitis: incretin-based drugs, fibroblast growth factor analogs, and liver-targeting strategiesSukwoo Han, Jaehee Shin, Jae Cheon Kim, Dong Hee Na · 2026 · Journal of Pharmaceutical Investigation
- Targeting PKLR and lipogenic enzymes through JNK inhibition to develop a therapeutic strategy for MASLD and MASHWoonghee Kim, Mengzhen Li, Xinmeng Liao, Sevilay Özmen, Edanur Yıldız, Melik Saraçoğlu, Cem Baba, Fatih Çağlar Çelikezen, Said Ali Atalay, Ahmet Tuğrul Akkuş et al. · 2026 · Frontiers in Pharmacology
- Discovery of Potent and Selective THRβ Agonists Based on an N -Benzoylglycine Scaffold for the Treatment of Metabolic DisordersYue Wu, Linjian Zhang, X Q Li, 曹瑞恆, Shuang Han, Shanrui Li, Wei Shen Aik, Haoshu Zhang, Peiyao Yang, Tiande Bing et al. · 2026 · Journal of Medicinal Chemistry
- Adipose Tissue Dysfunction in Metabolic Dysfunction-Associated Steatotic Liver DiseaseAndrew John Legaspi Cruz, Liyun Yuan · 2026 · Cells
- Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha‐Fatty‐Acid Amide Hydrolase 1 Signaling PathwayEva Nóvoa, Alba Cabaleiro, Borja López-Picallo, Natália da Silva Lima, C Riobello, Carmen Pena, Jose Iglesias-Moure, Ana Senra, Maria Luz Martínez‐Chantar, Anabel Fernández‐Iglesias et al. · 2026 · MedComm
- The role of thyroid hormone beta 1 receptor (THRβ1) in metabolic dysfunction associated steatohepatitis (MASH): from dysregulation to therapeutic target.R. Patil, G. Viswanatha, Sai Balaji Andugulapati, S. Bojja, Arvinda Pai, N. D. Satyanarayan, K. Nandakumar · 2026 · Biochemical Pharmacology
- Effects of MASH risk genotypes on resmetirom efficacy in patients with MASH and fibrosisNaga Chalasani, Rebecca A. Taub, Robin Mogg, Dominic Labriola, Raul C. Camacho, Hang Zhang, Quentin Mark Anstee · 2026 · Journal of Hepatology
- Potential for Cardiovascular Benefits of Resmetirom Based on LDL-Cholesterol and Lipoprotein(a) Lowering Consistent Across Statin Subgroups, a Secondary Analysis of the MAESTRO-NASH Phase 3 Clinical TrialMeena B. Bansal, Rebecca A. Taub, Dominic Labriola, David G. Soergel, Yestle Kim, Naim Alkhouri, Mazen Noureddin, Seth Baum, Rohit Loomba · 2026 · Journal of clinical lipidology
- AI-Driven Discovery Pipeline Identifies Carvedilol as a Novel Partial Agonist of THRβShuai Han, Chaochun Wei, Han Ju, Tongyu Huo, Tzumei Wang, Yameng Liu, Chao Wang, Zhenming Liu, Xiaodong Dou, Ning Jiao · 2026 · Journal of Chemical Information and Modeling
- BindingDB Entry 50048146: The therapeutic journey of pyridazinone.BindingDB · 2018 · UC San Diego
- BindingDB Entry 50022101: Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.BindingDB · 2025 · UC San Diego
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- BindingDB Entry 50007641: The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.BindingDB · 2021 · UC San Diego
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