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Cited by 252

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Origins of the Quinolone Class of Antibacterials: An Expanded “Discovery Story”: Miniperspective

Open access
Bisacchi, Gregory S.·2015·Journal of Medicinal Chemistry
DOI 10.1021/jm501881c
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Abstract

Published descriptions of the specific lines of research leading to the discovery of therapeutically important medicines, especially major new class medicines, have long provided value to the biopharmaceutical community as models of success, often influencing the strategies and methods of subsequent drug research. Quinolone antibacterials represent one of medicine's most important classes of anti-infective agents; yet in contrast to many other classes of anti-infectives, astonishingly few details concerning the origin of the class or the rationale leading to the selection of the first clinical agent, nalidixic acid, were ever published by the discoverers. Moreover, earlier disclosures of an independent discovery of the quinolone class of antibacterials have been almost entirely overlooked by the scientific literature. This review brings together all the available information from primary literature sources relating to both discoveries and provides for the first time a much fuller, if still partially speculative, story of the earliest years of this important class of drugs.

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Metadata

Authors
Bisacchi, G. S.
Venue
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Published
2015-03-12
Volume
58
Issue
12
Pages
4874-4882
ISSN
  • 0022-2623 (ISSN-L)
  • 1520-4804
DOI
10.1021/jm501881c
OpenAlex
W258250165
Cited by
252
References
24
FWCI
14.04
Type
journal article
Language
en
Open access
hybrid

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.