Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

Cavalli, Andrea, Bolognesi, Maria Laura, Minarini, Anna, Rosini, Michela, Tumiatti, Vincenzo, Recanatini, Maurizio, Melchiorre, Carlo·2008·Journal of Medicinal Chemistry
DOI 10.1021/jm7009364

Cites (242)

Items 201–239 of 239

  1. Recent Advances in the Development of Hybrid Molecules/Designed Multiple Compounds with Antiamnesic Properties
    Michael W. Decker · 2007 · Mini-Reviews in Medicinal Chemistry
  2. Clinical Trials in ALS: An Overview
    Martin R. Turner, Matthew J. Parton, P. Nigel Leigh · 2001 · Seminars in Neurology
  3. Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals
    Jose Luis Marco, Rafael M. Leon, Manuela G. López, Antonio G. Garcı́a, Mércedes Villarroya · 2006 · European Journal of Medicinal Chemistry
  4. A double-blind crossover pilot study of l-deprenyl (selegiline) combined with cholinesterase inhibitor in Alzheimer's disease
    Lon S. S. Schneider, Jason T. Olin, Sonia Pawluczyk · 1993 · American Journal of Psychiatry
  5. Statin-mediated protective effects in the central nervous system: General mechanisms and putative role of stress proteins
    Christian W. Schmeer, Alexandra Kretz, Stefan Isenmann · 2006 · Restorative Neurology and Neuroscience
  6. Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil
    Moussa B. H. Youdim, Tamar Amit, Orit Bar‐Am, Orly Weinreb, Mara Yogev-Falach · 2006 · Neurotoxicity Research
  7. Analysis of multifactorial disease
    BD Timothy, PC Sham · 2000 · Medical Entomology and Zoology
  8. Lipoic Acid, a Lead Structure for Multi-Target-Directed Drugs for Neurodegeneration
    María Laura Bolognesi, Anna Minarini, Vincenzo Tumiatti, Carlo Melchiorre · 2006 · Mini-Reviews in Medicinal Chemistry
  9. Metal homeostasis in Alzheimer’s disease
    Anthony Robert White, Kevin Jeffrey Barnham, Ashley Ian Bush · 2006 · Expert Review of Neurotherapeutics
  10. Design, synthesis and structure–Activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease
    Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki et al. · 2003 · Bioorganic & Medicinal Chemistry
  11. New Classes of AChE Inhibitors with Additional Pharmacological Effects of Interest for the Treatment of Alzheimers Disease
    Mércedes Villarroya, Antonio G. Garcı́a, J. Marco · 2004 · Current Pharmaceutical Design
  12. l-Deprenyl and physostigmine for the treatment of Alzheimer's disease
    Deborah B. Marin, Linda M. Bierer, BRIAN A. LAWLOR, Theresa M. Ryan, Rachel Jacobson, James Schmeidler, Richard C. Mohs, Kenneth L. Davis · 1995 · Psychiatry Research
  13. Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase
    David M. Fink, M.G. Palermo, Gina M. Bores, Francis P. Huger, Barbara E. Kurys, Michael C. Merriman, Gordon E. Olsen, Wayne W. Petko, Gerard J. O'Malley · 1996 · Bioorganic & Medicinal Chemistry Letters
  14. 3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl- 4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity
    David Bebbington, Nathaniel J. T. Monck, Suneel Gaur, Alan M. Palmer, Karen R. Benwell, Victoria L. Harvey, Craig S. Malcolm, Richard H. P. Porter · 2000 · Journal of Medicinal Chemistry
  15. Antioxidants and Oxidative Stress in Health and Disease: Introduction
    Tammy Μ. Bray · 1999 · Proceedings of The Society for Experimental Biology and Medicine
  16. Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant
    Wance J. J. Firdaus, Andreas Wyttenbach, Chantal Diaz‐Latoud, R. William Currie, André‐Patrick Arrigo · 2006 · FEBS Journal
  17. Structure−Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 3. Effect of Replacing the Inner Polymethylene Chain with Cyclic Moieties
    Vincenzo Tumiatti, Vincenza Andrisano, Rita Banzi, Manuela Bartolini, Anna Minarini, Michela Rosini, Carlo Melchiorre · 2004 · Journal of Medicinal Chemistry
  18. Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease
    Tara L. Spires‐Jones, Anthony John Hannan · 2006 · Journal of Neurochemistry
  19. Universal Template Approach to Drug Design: Polyamines as Selective Muscarinic Receptor Antagonists
    María Laura Bolognesi, Anna Minarini, Roberta Budriesi, Silvia Cacciaguerra, Alberto Chiarini, Santi Mario Spampinato, Vincenzo Tumiatti, Carlo Melchiorre · 1998 · Journal of Medicinal Chemistry
  20. Normal densities of 5-HT3 receptor recognition sites in Alzheimerʼs disease
    Nicholas M. Barnes, B. Costall, Robert J. Naylor, Timothy J. Williams, Claude M. Wischik · 1990 · Neuroreport
  21. Alzheimer's Disease:Progress in the Development of Anti-amyloid Disease-Modifying Therapies
    Daniel D. Christensen · 2007 · CNS Spectrums
  22. Multiple enzyme inhibitions by histamine H3 receptor antagonists as potential procognitive agents.
    Georg A. Petroianu, Kholoud Arafat, Britta C. Sasse, Holger Stark · 2006 · PubMed
  23. Multifunctional neuroprotective drugs for the treatment of cognitive and movement impairment disorders, including Alzheimer's and Parkinson's diseases
    Cornells J. Van der Schyf, Werner J. Geldenhuys, Moussa B. H. Youdim · 2006 · Drugs of the Future
  24. Therapeutic targets for amyotrophic lateral sclerosis: current treatments and prospects for more effective therapies
    Lucie I. Bruijn, Merit Cudkowicz · 2006 · Expert Review of Neurotherapeutics
  25. Polymethylene tetraamine backbone as template for the development of biologically active polyamines
    Carlo Melchiorre, Alessandra Antonello, Rita Banzi, María Laura Bolognesi, Anna Minarini, Michela Rosini, Vincenzo Tumiatti · 2002 · Medicinal Research Reviews
  26. Clinical experience with the novel levodopa formulation entacapone + levodopa + carbidopa (Stalevo®)
    Dee E. Silver · 2004 · Expert Review of Neurotherapeutics
  27. Turning from monogamy to strategic promiscuity
    Holger Stark · 2004 · Drug Discovery Today
  28. Progress in acetylcholinesterase inhibitors for Alzheimer’s disease
    María Laura Bolognesi, Anna Minarini, Vincenzo Tumiatti, Carlo Melchiorre · 2006 · Expert Opinion on Therapeutic Patents
  29. Neurochemical Effects of 3-[1-(Phenylmethyl)-4-Piperidinyl]-1-(2,3,4,5-Tetrahydro-1H-1-Benzazepin-8-yl)-1-Propanone Fumarate (TAK-147), a Novel Acetylcholinesterase Inhibitor, in Rats
    Keisuke Hirai, Koki Kato, T. Nakayama, Hitomi Hayako, Yuji Ishihara, Giichi Goto, Masaomi Miyamoto · 1997 · Journal of Pharmacology and Experimental Therapeutics
  30. Tetrahydroaminoacridine (THA) reduces voltage-dependent calcium currents in rat sensory neurons
    Kevin M. Kelly, Robert A. Gross, Robert L. Macdonald · 1991 · Neuroscience Letters
  31. Introduction: Amyloid-Based Interventions in Alzheimer's Disease
    Gary J. Kennedy · 2007 · CNS Spectrums
  32. Ropinirole: Current status of the studies
    WolfgangH. Jost · 2004 · Journal of Neurology
  33. Identification of Novel Multifunctional Compounds for the Treatment of Some Aging Related Neurodegenerative Diseases
    Laura Novaroli, Antoine Daina, Francesca Bertolini, Saviana Di Giovanni, Juan Bravo, Marianne Reist, Pierre‐Alain Carrupt · 2005 · CHIMIA International Journal for Chemistry
  34. The selectivity of MDL 74,721 in models of neurogenic versus vascular components of migraine
    Margaret A. Petty, Jack Elands, Michael P. Johnson, Matthew D. Linnik, Édith Hamel, Michael A. Moskowitz, Win Sok Lee, Deborah R. McCarty, Marcel Hibert, Bruce M. Baron · 1997 · European Journal of Pharmacology
  35. Inflammation and neurodegeneration
    Fredrik Piehl · 2005 · Future Neurology
  36. Initial Parkinson Disease Therapy
    Ewell Steve Roach · 2004 · Archives of Neurology
  37. Sarizotan Hydrochloride
    J.A. McIntyre, J. Castañer, M. Bayés · 2006 · Drugs of the Future
  38. A new strategy to combat Alzheimer＇s disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule
    Ji, Zhang, Hy · 2006 · 中国生物学文摘
  39. Cooperative Ideas about Cooperative Strategies
    Steven W. Barger · 2004 · Annals of the New York Academy of Sciences