The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Biosensor Analysis of the Interaction between Immobilized Human Serum Albumin and Drug Compounds for Prediction of Human Serum Albumin Binding Levels
Abstract
The interactions between a set of drugs, selected on the basis of reported human serum albumin (HSA) binding levels, and immobilized HSA were investigated using surface plasmon resonance technology. Major HSA binding sites were available after immobilization. The intensity of the signal obtained from the interaction of the drug with the HSA surface was correlated with the reported HSA binding level. Drugs were classified into groups corresponding to high, medium, or low HSA binding based on the injection of the drug at 80 microM concentration. A set of 10 drugs binding to alpha(1)-acid glycoprotein (AGP) was also investigated and correlated with reported AGP binding data. The throughput of the presented assay is 100 compounds/24 h, and the sample consumption is less than 100 microL (8 nmol).
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Self-citationDrug-protein binding studies new trends in analytical and experimental methodology
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Self-citationSurface plasmon resonance and its use in biomolecular interaction analysis (BIA)
Szabo, A., Stolz, L., & Granzow, R. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80064-6 · Cited by 238
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Self-citationPharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate.
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Optical biosensors in drug discovery
Cooper, M. A. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd838 · Cited by 1,015
Predicting plasma protein binding of drugs: a new approach
Kratochwil, N. A., Huber, W., Müller, F., Kansy, M., & Gerber, P. R. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01074-2 · Cited by 553
SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
Palacino, J., Swalley, S. E., Song, C., Cheung, A. K., Shu, L., Zhang, X., Van Hoosear, M., Shin, Y., Chin, D. N., Keller, C. G., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1837 · Cited by 432
Interactive Association of Drugs Binding to Human Serum Albumin
Yang, F., Zhang, Y., & Liang, H. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033580 · Cited by 376
Metadata
- Authors
- Frostell-Karlsson, Å., Remaeus, A., Roos, H., Andersson, K., Borg, P., Hämäläinen, M., & Karlsson, R.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-04-26
- Volume
- 43
- Issue
- 10
- Pages
- 1986-1992
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2046231111
- Cited by
- 310
- References
- 15
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frostell-Karlsson, Å., Remaeus, A., Roos, H., Andersson, K., Borg, P., Hämäläinen, M., & Karlsson, R. (2000). Biosensor Analysis of the Interaction between Immobilized Human Serum Albumin and Drug Compounds for Prediction of Human Serum Albumin Binding Levels. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm991174y
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