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Following the Dynamics of pH in Endosomes of Live Cells with SERS Nanosensors
Abstract
The surface enhanced Raman scattering (SERS) spectrum of a reporter molecule attached to gold or silver nanostructures, which is pH-sensitive, can deliver information on the local pH in the environment of the nanostructure. Here, we demonstrate the use of a mobile SERS nanosensor made from gold nanaoaggregates and 4-mercaptobenzoic acid (pMBA) attached as a reporter for monitoring changes in local pH of the cellular compartments of living NIH/3T3 cells. We show that SERS nanosensors enable the dynamics of local pH in individual live cells to be followed at subendosomal resolution in a timeline of cellular processes. This information is of basic interest for a better understanding of a broad range of physiological and metabolic processes as well as for a number of biotechnological applications.
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Citations
Cited by
Gold Nanoparticles in Chemical and Biological Sensing
Saha, K., Agasti, S. S., Kim, C., Li, X., & Rotello, V. M. (2012) · Chemical Reviews · doi:10.1021/cr2001178 · Cited by 4,620
Plasmons in Strongly Coupled Metallic Nanostructures
Halas, N. J., Lal, S., Chang, W.-S., Link, S., & Nordlander, P. (2011) · Chemical Reviews · doi:10.1021/cr200061k · Cited by 3,135
Recent progress in SERS biosensing
Bantz, K. C., Meyer, A. F., Wittenberg, N. J., Im, H., Kurtuluş, Ö., Lee, S. H., Lindquist, N. C., Oh, S.-H., & Haynes, C. L. (2011) · Physical Chemistry Chemical Physics · doi:10.1039/c0cp01841d · Cited by 620
Raman spectroscopy as a method to replace off‐line pH during mammalian cell culture processes
Rafferty, C., O'Mahony, J., Burgoyne, B., Rea, R., Balss, K. M., & Latshaw, D. C. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27197 · Cited by 31
Zhou, T., Rodríguez-Barrios, S., Ruisánchez, I., & Rivera-Gil, P. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.117897 · Cited by 4
Metadata
- Authors
- Kneipp, J., Kneipp, H., Wittig, B., & Kneipp, K.
- Venue
- The Journal of Physical Chemistry C
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-01-05
- Volume
- 114
- Issue
- 16
- Pages
- 7421-7426
- ISSN
- 1932-7447 (ISSN-L)
- 1932-7455
- OpenAlex
- W2036950867
- Cited by
- 205
- References
- 0
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kneipp, J., Kneipp, H., Wittig, B., & Kneipp, K. (2010). Following the Dynamics of pH in Endosomes of Live Cells with SERS Nanosensors. The Journal of Physical Chemistry C. https://doi.org/10.1021/jp910034z
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
