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Water-Soluble Hollow Nanospheres as Potential Drug Carriers
Abstract
A polyisoprene- block -poly(2-cinnamoylethyl methacrylate) (PI- b -PCEMA) sample with 88 units of isoprene and 2.3 × 10 2 units of CEMA formed vesicles in THF/hexanes with hexanes volume fractions between 50% and 95%. The vesicles had PCEMA as the shell and PI chains stretching into the solution phase from both the inner and outer surfaces of the PCEMA shell. The cavity diameter of the vesicles is ∼38 nm, and the volume fraction of PI chains there is low. After the PCEMA shell was cross-linked, the PI chains were converted to water-soluble poly(2,3-dihydroxyl-2-methyl-butane) chains. The water-soluble hollow nanospheres uptook a large amount of rhodamine B in methanol and released the compound into water at a tunable rate depending on the amount of ethanol added to the aqueous medium. This study demostrates the potential of hollow nanospheres, prepared from tailor-made biocompataible and degradable polymers, as drug carriers in controlled drug release applications.
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Cited by
Nano-engineering block copolymer aggregates for drug delivery
Allen, C., Maysinger, D., & Eisenberg, A. (1999) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/s0927-7765(99)00058-2 · Cited by 1,358
Nanostructure fabrication using block copolymers
Hamley, I. W. (2003) · Nanotechnology · doi:10.1088/0957-4484/14/10/201 · Cited by 773
Advanced drug delivery devices via self-assembly of amphiphilic block copolymers
Rösler, A., Vandermeulen, G. W. M., & Klok, H.-A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.026 · Cited by 688
Chen, D., & Jiang, M. (2005) · Accounts of Chemical Research · doi:10.1021/ar040113d · Cited by 371
Thermo-responsive shell cross-linked PMMA-b-P(NIPAAm-co-NAS) micelles for drug delivery
Chang, C., Wei, H., Wu, D.-Q., Yang, B., Chen, N., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.08.038 · Cited by 46
Metadata
- Authors
- Ding, J., & Liu, G.
- Venue
- The Journal of Physical Chemistry B
- Publisher
- American Chemical Society (ACS)
- Published
- 1998-07-01
- Volume
- 102
- Issue
- 31
- Pages
- 6107-6113
- ISSN
- 1520-5207 (ISSN-L)
- 1520-6106
- OpenAlex
- W1974102957
- Cited by
- 186
- References
- 0
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ding, J., & Liu, G. (1998). Water-Soluble Hollow Nanospheres as Potential Drug Carriers. The Journal of Physical Chemistry B. https://doi.org/10.1021/jp9805510
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