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Biomedical Applications of Shape-Controlled Plasmonic Nanostructures: A Case Study of Hollow Gold Nanospheres for Photothermal Ablation Therapy of Cancer
Abstract
Biomedical applications of plasmonic metal nanostructures represent new and exciting directions of research and development. For instance, photothermal ablation therapy (PTA) based on metal nanomaterials has been actively explored for treating cancer with encouraging success. PTA relies on heat generated from light for destroying cancer cells and thus requires strong optical absorption and high efficiency of photothermal conversion. Desired metal nanostructures for PTA should have strong and tunable SPR, low toxicity, ease of delivery, and convenience for bioconjugation for actively targeting cancer cells. Nanostructures of noble metals, for example, gold and silver, show great promise for PTA applications, including nanoparticles, nanorods, nanoshells, nanocages, and hollow nanospheres. Among these structures, hollow gold nanospheres exhibit a unique combination of small size, spherical shape, and strong, narrow, and tunable SPR. This Perspective highlights the importance of shape control in determining the optical and photothermal properties of metal nanostructures for PTA applications.
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Cites
Perspectives on the Physical Chemistry of Semiconductor Nanocrystals
Alivisatos, A. P. (1996) · The Journal of Physical Chemistry · doi:10.1021/jp9535506 · Cited by 3,595
Cited by
Li, G. L., Möhwald, H., & Shchukin, D. G. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35517a · Cited by 314
Bertorelle, F., Pinto, M., Zappon, R., Pilot, R., Litti, L., Fiameni, S., Conti, G., Gobbo, M., Toffoli, G., Colombatti, M., et al. (2018) · Nanoscale · doi:10.1039/c7nr07844g · Cited by 34
Photonically-Activated Molecular Excitations for Thermal Energy Conversion in Porphyrinic Compounds
Zhao, Y., Lin, J., Kundrat, D. M., Bonmarin, M., Krupczak, J., Thomas, S. V., Lyu, M., & Shi, D. (2020) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.9b09374 · Cited by 32
Metadata
- Authors
- Zhang, J. Z.
- Venue
- The Journal of Physical Chemistry Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-01-27
- Volume
- 1
- Issue
- 4
- Pages
- 686-695
- ISSN
- 1948-7185 (ISSN-L)
- OpenAlex
- W2023144913
- Cited by
- 290
- References
- 1
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Biomedical Applications of Shape-Controlled Plasmonic Nanostructures: A Case Study of Hollow Gold Nanospheres for Photothermal Ablation Therapy of Cancer. https://app.cochat.ai/papers/10.1021/jz900366c
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- Zhang, J. Z. (2010). Biomedical Applications of Shape-Controlled Plasmonic Nanostructures: A Case Study of Hollow Gold Nanospheres for Photothermal Ablation Therapy of Cancer. The Journal of Physical Chemistry Letters. https://doi.org/10.1021/jz900366c
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