The DOI matches its Crossref record.
Generation of Cytotoxic Singlet Oxygen via Phthalocyanine-Stabilized Gold Nanoparticles: A Potential Delivery Vehicle for Photodynamic Therapy
Abstract
Gold nanoparticles have been stabilized with a phthalocyanine (Pc) photosensitizer. Transmission electron microscopy confirmed that the coated particles were in the 2−4 nm size regime. Energy-dispersive X-ray analysis revealed that the Pc macrocycle was present on the gold surface and also that the TOAB phase transfer reagent, used during the synthesis, was associated with the nanoparticles. The three-component (photosensitizer/gold/phase transfer reagent) nanoparticles were shown to generate singlet oxygen with enhanced quantum yields as compared to the free Pc. Additionally, the association of the transfer reagent promoted the solubility of the surface-bound hydrophobic sensitizer in polar solvents which would facilitate their systemic injection. The results suggest that these three-component structures have potential as a useful vehicle for the delivery of photosensitizer agents in photodynamic therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Gold nanoparticles in delivery applications☆
GHOSH, P., HAN, G., DE, M., KIM, C., & ROTELLO, V (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.016 · Cited by 2,694
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Nanoparticles as vehicles for delivery of photodynamic therapy agents
Bechet, D., Couleaud, P., Frochot, C., Viriot, M.-L., Guillemin, F., & Barberi-Heyob, M. (2008) · Trends in Biotechnology · doi:10.1016/j.tibtech.2008.07.007 · Cited by 760
Cheng, Y., Samia, A. C., Meyers, J. D., Panagopoulos, I., Fei, B., & Burda, C. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801631c · Cited by 733
A Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle
Amina, S. J., & Guo, B. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s279094 · Cited by 561
Metadata
- Authors
- Hone, D. C., Walker, P. I., Evans-Gowing, R., FitzGerald, S., Beeby, A., Chambrier, I., Cook, M. J., & Russell, D. A.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-03-19
- Volume
- 18
- Issue
- 8
- Pages
- 2985-2987
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2092863438
- Cited by
- 306
- References
- 0
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Generation of Cytotoxic Singlet Oxygen via Phthalocyanine-Stabilized Gold Nanoparticles: A Potential Delivery Vehicle for Photodynamic Therapy. https://app.cochat.ai/papers/10.1021/la0256230
- The paper
- Hone, D. C., Walker, P. I., Evans-Gowing, R., FitzGerald, S., Beeby, A., Chambrier, I., Cook, M. J., & Russell, D. A. (2002). Generation of Cytotoxic Singlet Oxygen via Phthalocyanine-Stabilized Gold Nanoparticles: A Potential Delivery Vehicle for Photodynamic Therapy. Langmuir. https://doi.org/10.1021/la0256230
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
