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Glucose-oxidase Based Self-Destructing Polymeric Vesicles
Abstract
We have designed oxidation-responsive vesicles from synthetic amphiphilic block copolymers ("polymersomes") of ethylene glycol and propylene sulfide. Thioethers in the hydrophobic poly(propylene sulfide) block are converted into the more hydrophilic sulfoxides and sulfones upon exposure to an oxidative environment, changing the hydrophilic-lipophilic balance of the macroamphiphile and thus inducing its solubilization. Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system. We studied the encapsulation of GOx within polymersomes, its stability and activity, and glucose-triggered polymersome destabilization. Stimulus-responsive polymersomes may find applications as nanocontainers in sensing devices and as drug delivery systems.
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Citations
Cited by
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500
Stimuli-Responsive Polymersomes for Programmed Drug Delivery
Meng, F., Zhong, Z., & Feijen, J. (2009) · Biomacromolecules · doi:10.1021/bm801127d · Cited by 1,122
Discher, D. E., & Ahmed, F. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095838 · Cited by 844
Motornov, M., Roiter, Y., Tokarev, I., & Minko, S. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.10.004 · Cited by 773
Enzyme-responsive nanoparticles for drug release and diagnostics
de la Rica, R., Aili, D., & Stevens, M. M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.002 · Cited by 765
Metadata
- Authors
- Napoli, A., Boerakker, M. J., Tirelli, N., Nolte, R. J. M., Sommerdijk, N. A. J. M., & Hubbell, J. A.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-03-31
- Volume
- 20
- Issue
- 9
- Pages
- 3487-3491
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W1979534169
- Cited by
- 241
- References
- 0
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Napoli, A., Boerakker, M. J., Tirelli, N., Nolte, R. J. M., Sommerdijk, N. A. J. M., & Hubbell, J. A. (2004). Glucose-oxidase Based Self-Destructing Polymeric Vesicles. Langmuir. https://doi.org/10.1021/la0357054
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