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The Rheological and Structural Properties of Fmoc-Peptide-Based Hydrogels: The Effect of Aromatic Molecular Architecture on Self-Assembly and Physical Characteristics
Abstract
Biocompatible hydrogels are of high interest as a class of biomaterials for tissue engineering, regenerative medicine, and controlled drug delivery. These materials offer three-dimensional scaffolds to support the growth of cells and development of hierarchical tissue structures. Fmoc-peptides were previously demonstrated as attractive building blocks for biocompatible hydrogels. Here, we further investigate the biophysical properties of Fmoc-peptide-based hydrogels for medical applications. We describe the structural and thermal properties of these Fmoc-peptides, as well as their self-assembly process. Additionally, we study the role of interactions between aromatic moieties in the self-assembly process and on the physical and structural properties of the hydrogels.
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Cites
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
A tough biodegradable elastomer
Wang, Y., Ameer, G. A., Sheppard, B. J., & Langer, R. (2002) · Nature Biotechnology · doi:10.1038/nbt0602-602 · Cited by 1,314
Cited by
Functional π-Gelators and Their Applications
Babu, S. S., Praveen, V. K., & Ajayaghosh, A. (2014) · Chemical Reviews · doi:10.1021/cr400195e · Cited by 1,725
Tao, K., Levin, A., Adler-Abramovich, L., & Gazit, E. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00889a · Cited by 482
Self-citation
Metadata
- Authors
- Orbach, R., Mironi-Harpaz, I., Adler-Abramovich, L., Mossou, E., Mitchell, E. P., Forsyth, V. T., Gazit, E., & Seliktar, D.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-01-12
- Volume
- 28
- Issue
- 4
- Pages
- 2015-2022
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2335729371
- Cited by
- 189
- References
- 2
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Orbach, R., Mironi-Harpaz, I., Adler-Abramovich, L., Mossou, E., Mitchell, E. P., Forsyth, V. T., Gazit, E., & Seliktar, D. (2012). The Rheological and Structural Properties of Fmoc-Peptide-Based Hydrogels: The Effect of Aromatic Molecular Architecture on Self-Assembly and Physical Characteristics. Langmuir. https://doi.org/10.1021/la204426q
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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