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Microwave-Assisted Polyol Synthesis of Gadolinium-Doped Green Luminescent Carbon Dots as a Bimodal Nanoprobe

Gong, Ningqiang, Wang, Hao, Li, Shuai, Deng, Yunlong, Chen, Xiao’ai, Ye, Ling, Gu, Wei·2014·Langmuir
DOI 10.1021/la502705g
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Abstract

The development of multimodal nanoprobes is highly desired in medical imaging because it integrates the advantages of multiple imaging modes. In this study, the gadolinium-doped green luminescent carbon dots (Gd-CDs) were prepared by the simple one-step microwave-assisted polyol method. The obtained Gd-CDs emitted a unique green photoluminescence with a quantum yield of 5.4%. The Gd-CDs exhibited a low cytotoxicity and could optically label the C6 glioma cells. Meanwhile, the r1 relaxivity of Gd-CDs was measured to be 11.356 mM(-1) s(-1). This high r1 value together with the r2/r1 ratio close to 1 nominates Gd-CDs as an excellent T1 contrast agent for magnetic resonance imaging. These Gd-CDs combining two complementary imaging modalities are therefore a promising bimodal nanoprobe in medical imaging for a better diagnosis.

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Metadata

Authors
Gong, N., Wang, H., Li, S., Deng, Y., Chen, X., Ye, L., & Gu, W.
Venue
Langmuir
Publisher
American Chemical Society (ACS)
Published
2014-09-07
Volume
30
Issue
36
Pages
10933-10939
ISSN
  • 0743-7463 (ISSN-L)
  • 1520-5827
DOI
10.1021/la502705g
OpenAlex
W2316630725
Cited by
200
References
0
FWCI
7.30
Type
journal article
Language
en
Open access
closed
Funders
Natural Science Foundation of China (81271639)

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Gong, N., Wang, H., Li, S., Deng, Y., Chen, X., Ye, L., & Gu, W. (2014). Microwave-Assisted Polyol Synthesis of Gadolinium-Doped Green Luminescent Carbon Dots as a Bimodal Nanoprobe. Langmuir. https://doi.org/10.1021/la502705g

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