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Controlled Association of Amphiphilic Polymers in Water: Thermosensitive Nanoparticles Formed by Self-Assembly of Hydrophobically Modified Pullulans and Poly(N-isopropylacrylamides)
Abstract
Thermoresponsive hydrogel nanoparticles were prepared by self-assembly of two different hydrophobically modified polymers, namely a cholesterol-bearing pullulan (CHP) and a copolymer of N -isopropylacrylamide (NIPAM) and N -[4-(1-pyrenyl)butyl]- N - n -octadecylacrylamide] (PNIPAM-C 18 Py). The interactions between CHP and PNIPAM-C 18 Py were investigated by fluorescence spectroscopy, dynamic light scattering, and size exclusion chromatography. After ultrasonication of a mixture of CHP and PNIPAM-C 18 Py (5:1 by weight) at 25 °C, monodisperse nanoparticles (Dh = 45 nm) were obtained, consisting of self-assembly of the two polymers associated via their hydrophobic moieties. Evidence from fluorescence and dynamic light scattering demonstrated that, above 32 °C, the lower critical solution temperature (LCST) of PNIPAM-C 18 Py, the colloidal mixed nanoparticles increase in diameter (from 47 to 160 nm), but no macroscopic aggregation could be detected. This phenomenon was thermoreversible: upon cooling the particles recovered their original diameter.
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Cited by
Stimuli-reponsive polymers and their bioconjugates
GIL, E., & HUDSON, S. (2004) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2004.08.003 · Cited by 2,385
Recent advances in the structure, synthesis, and applications of natural polymeric hydrogels
Gul, K., Gan, R.-Y., Sun, C.-X., Jiao, G., Wu, D.-T., Li, H.-B., Kenaan, A., Corke, H., & Fang, Y.-P. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1870034 · Cited by 144
Metadata
- Authors
- Akiyoshi, K., Kang, E.-C., Kurumada, S., Sunamoto, J., Principi, T., & Winnik, F. M.
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-04-06
- Volume
- 33
- Issue
- 9
- Pages
- 3244-3249
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2052149500
- Cited by
- 160
- References
- 0
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Akiyoshi, K., Kang, E.-C., Kurumada, S., Sunamoto, J., Principi, T., & Winnik, F. M. (2000). Controlled Association of Amphiphilic Polymers in Water: Thermosensitive Nanoparticles Formed by Self-Assembly of Hydrophobically Modified Pullulans and Poly(N-isopropylacrylamides). Macromolecules. https://doi.org/10.1021/ma991798d
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