The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides
Open accessAbstract
Most peptides are generally insufficiently permeable to be used as oral drugs. Designing peptides with improved permeability without reliable permeability monitoring is a challenge. We have developed a supercritical fluid chromatography technique for peptides, termed EPSA, which is shown here to enable improved permeability design. Through assessing the exposed polarity of a peptide, this technique can be used as a permeability surrogate.
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Citations
Cites
Improving Oral Bioavailability of Peptides by Multiple N‐Methylation: Somatostatin Analogues
Biron, E., Chatterjee, J., Ovadia, O., Langenegger, D., Brueggen, J., Hoyer, D., Schmid, H. A., Jelinek, R., Gilon, C., Hoffman, A., et al. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200705797 · Cited by 374
Cited by
Macrocycles: lessons from the distant past, recent developments, and future directions
Yudin, A. K. (2015) · Chemical Science · doi:10.1039/c4sc03089c · Cited by 493
Orally Absorbed Cyclic Peptides
Nielsen, D. S., Shepherd, N. E., Xu, W., Lucke, A. J., Stoermer, M. J., & Fairlie, D. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00838 · Cited by 445
Edmondson, S. D., Yang, B., & Fallan, C. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.04.030 · Cited by 422
Bockus, A. T., Schwochert, J. A., Pye, C. R., Townsend, C. E., Sok, V., Bednarek, M. A., & Lokey, R. S. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00919 · Cited by 135
O’ Donovan, D. H., De Fusco, C., Kuhnke, L., & Reichel, A. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01577 · Cited by 83
Metadata
- Authors
- Goetz, G. H., Philippe, L., & Shapiro, M. J.
- Venue
- ACS Medicinal Chemistry Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-08-11
- Volume
- 5
- Issue
- 10
- Pages
- 1167-1172
- ISSN
- 1948-5875 (ISSN-L)
- OpenAlex
- W2323894347
- Cited by
- 160
- References
- 1
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Goetz, G. H., Philippe, L., & Shapiro, M. J. (2014). EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides. ACS Medicinal Chemistry Letters. https://doi.org/10.1021/ml500239m
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
