The DOI matches its Crossref record.
Left-Handed Helical Ribbon Intermediates in the Self-Assembly of a β-Sheet Peptide
Abstract
We report the observation of intermediate structures in the self-assembly of the peptide KFE8 (FKFEFKFE), designed with alternating polar and nonpolar amino acids. Self-assembly was followed over time using atomic force microscopy (AFM), transmission electron microscopy (TEM), and circular dichroism (CD). Molecular dynamics simulations suggest that these intermediates are left-handed double helical β-sheets. These findings have implications in the study of β-sheet fibril formation, and in the molecular design of materials.
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Citations
Cited by
Fabrication of novel biomaterials through molecular self-assembly
Zhang, S. (2003) · Nature Biotechnology · doi:10.1038/nbt874 · Cited by 3,347
Self-citationKisiday, J., Jin, M., Kurz, B., Hung, H., Semino, C., Zhang, S., & Grodzinsky, A. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142309999 · Cited by 1,045
Self-citationCollagen-based biomaterials for wound healing
Chattopadhyay, S., & Raines, R. T. (2014) · Biopolymers · doi:10.1002/bip.22486 · Cited by 1,041
Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354
Multicomponent peptide assemblies
Raymond, D. M., & Nilsson, B. L. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00115d · Cited by 346
Gonzalez-Diaz, H., Arrasate, S., Gomez-SanJuan, A., Sotomayor, N., Lete, E., Besada-Porto, L., & Ruso, J. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611313140011 · Cited by 101
(2008) · doi:10.1017/cbo9780511536557.022 · Cited by 4
Metadata
- Authors
- Marini, D. M., Hwang, W., Lauffenburger, D. A., Zhang, S., & Kamm, R. D.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-02-21
- Volume
- 2
- Issue
- 4
- Pages
- 295-299
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2088599251
- Cited by
- 314
- References
- 0
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
